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Issue 23, 2015
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Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

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Abstract

A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C60(E)12 bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.

Graphical abstract: Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

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Article information


Submitted
07 Apr 2015
Accepted
29 Apr 2015
First published
29 Apr 2015

Org. Biomol. Chem., 2015,13, 6482-6492
Article type
Paper
Author version available

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

K. Buffet, E. Gillon, M. Holler, J. Nierengarten, A. Imberty and S. P. Vincent, Org. Biomol. Chem., 2015, 13, 6482
DOI: 10.1039/C5OB00689A

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