Issue 23, 2015

Genetic encoding of the post-translational modification 2-hydroxyisobutyryl-lysine

Abstract

We report the synthesis and genetic encoding of a recently discovered post-translational modification, 2-hydroxyisobutyryl-lysine, to the genetic code of E. coli. The production of homogeneous proteins containing this amino acid will facilitate the study of modification in full-length proteins.

Graphical abstract: Genetic encoding of the post-translational modification 2-hydroxyisobutyryl-lysine

Supplementary files

Article information

Article type
Communication
Submitted
10 Feb 2015
Accepted
07 May 2015
First published
07 May 2015

Org. Biomol. Chem., 2015,13, 6479-6481

Genetic encoding of the post-translational modification 2-hydroxyisobutyryl-lysine

W. A. Knight and T. A. Cropp, Org. Biomol. Chem., 2015, 13, 6479 DOI: 10.1039/C5OB00283D

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