Issue 32, 2015

POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

Abstract

The increasing use of nanoparticles in the pharmaceutical industry is generating concomitant interest in developing nanomaterials that can rapidly penetrate into, and permeate through, biological membranes to facilitate drug delivery and improve the bioavailability of active pharmaceutical ingredients. Here, we demonstrate that the permeation of thiolated silica nanoparticles through porcine gastric mucosa can be significantly enhanced by their functionalization with either 5 kDa poly(2-ethyl-2-oxazoline) or poly(ethylene glycol). Nanoparticle diffusion was assessed using two independent techniques; Nanoparticle Tracking Analysis, and fluorescence microscopy. Our results show that poly(2-ethyl-2-oxazoline) and poly(ethylene glycol) have comparable abilities to enhance diffusion of silica nanoparticles in mucin dispersions and through the gastric mucosa. These findings provide a new strategy in the design of nanomedicines, by surface modification or nanoparticle core construction, for enhanced transmucosal drug delivery.

Graphical abstract: POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

Supplementary files

Article information

Article type
Paper
Submitted
14 May 2015
Accepted
14 Jul 2015
First published
17 Jul 2015
This article is Open Access
Creative Commons BY license

Nanoscale, 2015,7, 13671-13679

Author version available

POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

E. D. H. Mansfield, K. Sillence, P. Hole, A. C. Williams and V. V. Khutoryanskiy, Nanoscale, 2015, 7, 13671 DOI: 10.1039/C5NR03178H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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