RhIII-catalyzed dual directing group assisted sterically hindered C–H bond activation: a unique route to meta and ortho substituted benzofurans†
Abstract
A new strategy for the synthesis of highly substituted benzofurans from meta-substituted hydroxybenzenes and alkynes via a rhodium(III)-catalyzed activation of a sterically hindered C–H bond is demonstrated. A possible mechanism involving dual directing group assisted ortho C–H bond activation is proposed.