Palladium-catalyzed synthesis of nitriles from amides has been described. Two similar, but complementary reaction conditions have been identified to convert various amides including α,β,γ,δ-unsaturated amides, cinnamides, aromatic amides and alkyl amides to the corresponding nitriles in good to excellent yield.
W. Zhang, C. W. Haskins, Y. Yang and M. Dai, Org. Biomol. Chem., 2014, 12, 9109 DOI: 10.1039/C4OB01825G
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