Issue 82, 2014
From the journal:

Chemical Communications

Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy†

Shoji Tachikawa,ab   Tatsuro Miyoshi,b   Hayato Koganei,b   Mohamed E. El-Zaria,bc   Clara Viñas,d   Minoru Suzuki,e   Koji Onoe  and  Hiroyuki Nakamura*ab  

* Corresponding authors

a Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan
E-mail: hiro@res.titech.ac.jp
Fax: +81 45 924 5244

b Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan

c Department of Chemistry, Faculty of Science, Tanta University, 31527-Tanta, Egypt

d Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus U.A.B., 08193 Bellaterra, Barcelona, Spain

e Particle Radiation Oncology Research Center, Kyoto University Research Reactor Institute, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan

Abstract

closo-Dodecaborate-encapsulating liposomes were developed as boron delivery vehicles for neutron capture therapy. The use of spermidinium as a counter cation of closo-dodecaborates was essential not only for the preparation of high boron content liposome solutions but also for efficient boron delivery to tumors.

Graphical abstract: Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy

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Article information

DOI
https://doi.org/10.1039/C4CC04344H
Article type
Communication
Submitted
09 Jun 2014
Accepted
21 Aug 2014
First published
21 Aug 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 12325-12328

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Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy

S. Tachikawa, T. Miyoshi, H. Koganei, M. E. El-Zaria, C. Viñas, M. Suzuki, K. Ono and H. Nakamura, Chem. Commun., 2014, 50, 12325 DOI: 10.1039/C4CC04344H

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