Issue 82, 2014
From the journal:

Chemical Communications

Aptamer-based cell imaging reagents capable of fluorescence switching†

Yun Kyung Jung,ab   Min-Ah Woo,a   H. Tom Soh*c  and  Hyun Gyu Park*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering (BK21 + Program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea
E-mail: hgpark@kaist.ac.kr

b School of Natural Science, UNIST, UNIST-gil 50, Eonyang-eup, Ulju-gun, Ulsan 689-798, Republic of Korea

c Materials Department, Department of Mechanical Engineering, University of California, Santa Barbara, CA 93106, USA
E-mail: tsoh@engr.ucsb.edu

Abstract

We describe an aptamer-conjugated polydiacetylene imaging probe (ACP) that shows highly specific fluorescence switching upon binding to epithelial cancer cells that overexpress the tumor biomarker protein EpCAM (epithelial cell adhesion molecule) on their surface.

Graphical abstract: Aptamer-based cell imaging reagents capable of fluorescence switching

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Article information

DOI
https://doi.org/10.1039/C4CC03888F
Article type
Communication
Submitted
21 May 2014
Accepted
21 Aug 2014
First published
22 Aug 2014

Chem. Commun., 2014,50, 12329-12332

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Aptamer-based cell imaging reagents capable of fluorescence switching

Y. K. Jung, M. Woo, H. T. Soh and H. G. Park, Chem. Commun., 2014, 50, 12329 DOI: 10.1039/C4CC03888F

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