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Issue 1, 2012
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Dynamic combinatorial libraries for the recognition of heavy metal ions

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Abstract

We present the use of hydrazone dynamic combinatorial libraries (DCLs) to identify macrocyclic receptors that are selective for alkaline earth metal ions over alkali metal ions. In particular, the toxic heavy metal ions Sr2+ and Ba2+ induce characteristic changes in the DCLs. Four macrocycles were isolated and characterised by LCMS, HRMS, NMR and X-ray crystallography; binding studies by UV-Vis spectroscopy confirm the selectivity observed in the DCLs.

Graphical abstract: Dynamic combinatorial libraries for the recognition of heavy metal ions

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Article information


Submitted
16 Jun 2011
Accepted
08 Sep 2011
First published
25 Oct 2011

Org. Biomol. Chem., 2012,10, 60-66
Article type
Paper

Dynamic combinatorial libraries for the recognition of heavy metal ions

J. M. Klein, V. Saggiomo, L. Reck, U. Lüning and J. K. M. Sanders, Org. Biomol. Chem., 2012, 10, 60
DOI: 10.1039/C1OB05976A

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