Issue 1, 2012

Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorine

Abstract

A short and efficient synthesis of an advanced intermediate (1) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy.

Graphical abstract: Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorine

Supplementary files

Article information

Article type
Paper
Submitted
12 Aug 2011
Accepted
01 Sep 2011
First published
01 Sep 2011

Org. Biomol. Chem., 2012,10, 67-69

Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorine

C. Gignoux, A. F. Newton, A. Barthelme, W. Lewis, M. Alcaraz and R. A. Stockman, Org. Biomol. Chem., 2012, 10, 67 DOI: 10.1039/C1OB06380D

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