Issue 2, 2012
From the journal:

MedChemComm

Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones†

Allimuthu T. Dharmaraja,a   Tapan K. Dash,b   V. Badireenath Konkimalla*b  and  Harinath Chakrapani*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Pune, Maharashtra, India
E-mail: harinath@iiserpune.ac.in
Fax: +91-20-2589-9790
Tel: +91-20-2590-8090

b School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, Orissa, India
E-mail: badireenath@niser.ac.in
Fax: +91-674-230-4070
Tel: +91-674-230-4121

Abstract

Here, we report that thiol-mediated decomposition of 2,3-epoxy-1,4-naphthoquinones to generate peroxide, a reactive oxygen species (ROS), could be modulated by changing the substitution pattern on the aryl ring and the epoxide. Epoxides which generated higher amounts of peroxide upon reaction with thiols were better inhibitors of human leukaemia (THP1) cell proliferation.

Graphical abstract: Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

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Article information

DOI
https://doi.org/10.1039/C1MD00234A
Article type
Concise Article
Submitted
14 Sep 2011
Accepted
17 Oct 2011
First published
26 Oct 2011

Med. Chem. Commun., 2012,3, 219-224

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Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

A. T. Dharmaraja, T. K. Dash, V. B. Konkimalla and H. Chakrapani, Med. Chem. Commun., 2012, 3, 219 DOI: 10.1039/C1MD00234A

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