Issue 2, 2012
From the journal:

MedChemComm

Syntheses of a new class of phenyl butyraldehyde-derived amines with in vitro trypanocide activities†

María Fernanda Plano,a   Raquel M. Cravero,*a   Isabel Nocito,b   Esteban Serra,b   Sergio A. Guerreroc  and  Diego G. Ariasc  

* Corresponding authors

a Area Química Orgánica, IQUIR-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Argentina

b Area Parasitología, IBR-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario, Argentina

c Laboratorio de Bioquímica Microbiana, Cátedra de Parasitología, Facultad de Bioquímica y Cs. Biológicas, Universidad Nacional del Litoral, Ciudad Universitaria-Paraje El Pozo, Santa Fe, Argentina

Abstract

A new series of secondary and tertiary amines were prepared by reductive amination of synthetic phenyl-butyraldehydes and evaluated for their in vitro activity against Trypanosoma cruzi.

Graphical abstract: Syntheses of a new class of phenyl butyraldehyde-derived amines with in vitro trypanocide activities

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Article information

DOI
https://doi.org/10.1039/C1MD00237F
Article type
Concise Article
Submitted
15 Sep 2011
Accepted
12 Oct 2011
First published
14 Nov 2011

Med. Chem. Commun., 2012,3, 225-228

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Syntheses of a new class of phenyl butyraldehyde-derived amines with in vitro trypanocide activities

M. F. Plano, R. M. Cravero, I. Nocito, E. Serra, S. A. Guerrero and D. G. Arias, Med. Chem. Commun., 2012, 3, 225 DOI: 10.1039/C1MD00237F

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