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Issue 2, 2012
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3-Substituted coumarins as dual inhibitors of AChE and MAO for the treatment of Alzheimer's disease

Dolores Viña,a   Maria João Matos,*b   Matilde Yáñez,a   Lourdes Santanab  and  Eugenio Uriarteb  
Author affiliations

* Corresponding authors

a Departamento de Farmacología, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
E-mail: mdoloresvina@usc.es
Fax: +34 98159 4595
Tel: +34 9815 63100

b Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
E-mail: mariajoao.correiapinto@rai.usc.es
Fax: +34 981 544912
Tel: +34 981 563100

Abstract

The complex etiology of Alzheimer's disease (AD) has encouraged active research in the development of multi-target drugs with two or more complementary biological activities, since they may represent an important advance in the treatment of this disease. A series of 3-substituted coumarins were synthesized and evaluated as monoamino oxidases (MAO) and acetylcholinesterase (AChE) inhibitors. Most of the 3-benzamide coumarin derivatives inhibited both MAO-B and AChE with values in the micromolar range. It might be a promising direction for developing novel drugs as potential agents for the treatment of AD patients.

Graphical abstract: 3-Substituted coumarins as dual inhibitors of AChE and MAO for the treatment of Alzheimer's disease

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Publication details

The article was received on 30 Aug 2011, accepted on 03 Oct 2011 and first published on 26 Oct 2011


Article type: Concise Article
DOI: 10.1039/C1MD00221J
Med. Chem. Commun., 2012,3, 213-218

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    3-Substituted coumarins as dual inhibitors of AChE and MAO for the treatment of Alzheimer's disease

    D. Viña, M. J. Matos, M. Yáñez, L. Santana and E. Uriarte, Med. Chem. Commun., 2012, 3, 213
    DOI: 10.1039/C1MD00221J

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