Jump to main content
Jump to site search

Issue 2, 2012
Previous Article Next Article

Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

Author affiliations

Abstract

Here, we report that thiol-mediated decomposition of 2,3-epoxy-1,4-naphthoquinones to generate peroxide, a reactive oxygen species (ROS), could be modulated by changing the substitution pattern on the aryl ring and the epoxide. Epoxides which generated higher amounts of peroxide upon reaction with thiols were better inhibitors of human leukaemia (THP1) cell proliferation.

Graphical abstract: Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Sep 2011, accepted on 17 Oct 2011 and first published on 26 Oct 2011


Article type: Concise Article
DOI: 10.1039/C1MD00234A
Med. Chem. Commun., 2012,3, 219-224

  •   Request permissions

    Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

    A. T. Dharmaraja, T. K. Dash, V. B. Konkimalla and H. Chakrapani, Med. Chem. Commun., 2012, 3, 219
    DOI: 10.1039/C1MD00234A

Search articles by author

Spotlight

Advertisements