Issue 19, 2010

Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation

Abstract

A surprisingly efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation is developed. This reaction involves a key gold catalysis and shows generally high regioselectivities and good to excellent diastereoselectivities.

Graphical abstract: Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation

Supplementary files

Article information

Article type
Communication
Submitted
20 Jan 2010
Accepted
18 Feb 2010
First published
30 Mar 2010

Chem. Commun., 2010,46, 3351-3353

Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation

L. Cui, L. Ye and L. Zhang, Chem. Commun., 2010, 46, 3351 DOI: 10.1039/C001314E

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