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Issue 19, 2010
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Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S)

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Abstract

α-Methylacyl-CoA racemase (AMACR; P504S) catalysed exchange of straight-chain fatty acyl-CoA α-protons. One α-proton was removed in each catalytic cycle, with the pro-S proton preferred. This reaction was most efficient for straight-chain substrates with longer side-chains. 2-Methyldecanoyl-CoA underwent α-proton exchange 3× more efficiently (as judged by Kcat/Km) than decanoyl-CoA.

Graphical abstract: Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S)

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Article information


Submitted
05 Feb 2010
Accepted
09 Mar 2010
First published
30 Mar 2010

Chem. Commun., 2010,46, 3348-3350
Article type
Communication

Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S)

F. A. Sattar, D. J. Darley, F. Politano, T. J. Woodman, M. D. Threadgill and M. D. Lloyd, Chem. Commun., 2010, 46, 3348
DOI: 10.1039/C002509G

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