Issue 12, 2008

Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Abstract

The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

Graphical abstract: Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Supplementary files

Article information

Article type
Communication
Submitted
22 Feb 2008
Accepted
15 Apr 2008
First published
24 Apr 2008

Org. Biomol. Chem., 2008,6, 2058-2060

Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

K. Nakamura, Y. Tachikawa, M. Kitamura, O. Ohno, M. Suganuma and D. Uemura, Org. Biomol. Chem., 2008, 6, 2058 DOI: 10.1039/B803107J

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