Issue 12, 2008

A chiral thioureido acid as an effective additive for enantioselective organocatalytic Michael additions of nitroolefins

Abstract

A novel and effective organocatalytic system consisting of pyrrolidinyl-thioimidazole and a chiral thioureido acid efficiently catalyzed the asymmetric Michael addition reactions of ketones to nitroolefins to afford the adducts with high diastereoselectivities (up to 99 : 1) and excellent enantioselectivities (up to 99% ee).

Graphical abstract: A chiral thioureido acid as an effective additive for enantioselective organocatalytic Michael additions of nitroolefins

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2008
Accepted
22 Apr 2008
First published
16 May 2008

Org. Biomol. Chem., 2008,6, 2054-2057

A chiral thioureido acid as an effective additive for enantioselective organocatalytic Michael additions of nitroolefins

D. Xu, H. Yue, S. Luo, A. Xia, S. Zhang and Z. Xu, Org. Biomol. Chem., 2008, 6, 2054 DOI: 10.1039/B804541K

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