Issue 12, 2008

A direct and stereospecific approach to the synthesis of α-glycosyl thiols

Abstract

A new simple method for the synthesis of α-glycosyl thiols is described. Ring-opening of 1,6-anhydrosugars with commercially available bis(trimethylsilyl)sulfide under the action of catalytic amounts of TMSOTf smoothly afforded α-glycosyl thiols in very high yields and in a stereospecific way.

Graphical abstract: A direct and stereospecific approach to the synthesis of α-glycosyl thiols

Supplementary files

Article information

Article type
Communication
Submitted
19 Mar 2008
Accepted
16 Apr 2008
First published
30 Apr 2008

Org. Biomol. Chem., 2008,6, 2061-2063

A direct and stereospecific approach to the synthesis of α-glycosyl thiols

R. T. Dere, Y. Wang and X. Zhu, Org. Biomol. Chem., 2008, 6, 2061 DOI: 10.1039/B804536D

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