Issue 22, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Highly diastereoselective synthesis of β-amino alcohols

Wim J. N. Meester,a   Rudmer van Dijk,a   Jan H. van Maarseveen,a   Floris P. J. T. Rutjes,*ab   Pedro H. H. Hermkensc  and  Henk Hiemstra*a  

* Corresponding authors

a Institute of Molecular Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands

b Department of Organic Chemistry, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

c Lead Discovery Unit, NV Organon, P.O. Box 20, 5340 BH Oss, The Netherlands

Abstract

Several substituted β-amino alcohols 1 were synthesised in a diastereoselective manner via the novel highly versatile intermediate 8b, involving a combination of N-acyliminium ion and Weinreb amide chemistry.

Graphical abstract: Highly diastereoselective synthesis of β-amino alcohols

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B108254J
Article type
Communication
Submitted
02 Sep 2001
Accepted
10 Oct 2001
First published
25 Oct 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 2909-2911

Permissions

Request permissions

Highly diastereoselective synthesis of β-amino alcohols

W. J. N. Meester, R. van Dijk, J. H. van Maarseveen, F. P. J. T. Rutjes, P. H. H. Hermkens and H. Hiemstra, J. Chem. Soc., Perkin Trans. 1, 2001, 2909 DOI: 10.1039/B108254J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements