Structure elucidation of a glycopeptide antibiotic, OA-7653
Abstract
The structure of a vancomycin-type antibiotic, OA-7653, isolated from Streptomyces hygroscopicus subsp. hiwasaensis subsp. nov. Nishida, has been elucidated by a combination of classical chemical methods, mass spectrometry, and nuclear magnetic resonance spectroscopy. The interaction of OA-7653 with the peptide cell wall analogues N-acetyl-D-alanyl-D-alanine, and di-N-acetyl-L-lysyl-D-alanyl-D-alanine, in solution in aqueous dimethyl sulphoxide, has been examined by n.m.r. and u.v. difference spectroscopy.