The cobalt(II) complex of the simple polyketide model methyl 3,5-dioxohexanoate is regioselectively alkylated to afford methyl 4-alkyl-3,5-dioxohexanoates, which cyclize on treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give 5-alkyl-4-hydroxy-6-methyl-2-pyrones.
J. Cervelló, J. Marquet and M. Moreno-Mañas, J. Chem. Soc., Chem. Commun., 1987, 644 DOI: 10.1039/C39870000644
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