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Correction: ROS self-generation and hypoxia self-enhanced biodegradable magnetic nanotheranostics for targeted tumor therapy
Jinghua
Li
a,
Yun
Liu
b,
Xiaonan
Li
a,
Gaofeng
Liang
b,
Changshun
Ruan
*c and
Kaiyong
Cai
*d
aSchool of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, P. R. China
bResearch Center for Medicine and Biology, Zunyi Medical University, Zunyi 563003, P. R. China
cResearch Center for Human Tissue and Organs Degeneration Institute Biomedical and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China
dKey Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, P. R. China
First published on 10th April 2025
Abstract
Correction for ‘ROS self-generation and hypoxia self-enhanced biodegradable magnetic nanotheranostics for targeted tumor therapy’ by Jinghua Li et al., Nanoscale Horiz., 2020, 5, 350–358, https://doi.org/10.1039/C9NH00490D.
The authors apologise that due to some inadvertent errors during figure assembly, wrong images were used in Fig. 3g and 7m. The corrected figures are shown below. The authors are sorry for the mistake and would like to state that the errors do not influence the original conclusions for this manuscript.
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| Fig. 3 In vitro evaluations. (a) TEM images of HeLa cell incubation with MMNCs@PCM@Vc before and after AMF (4 kW, 300 A and 200 kHz) application. (b) Relative survival of HeLa cells under various concentrations of MMNCs@PCM@Vc for 24 h (n = 5). (c) Relative cytotoxicity of Vc (0–20 mM) on different types of normal and tumor cells. EC50 values indicate the concentration of Vc that reduced survival by 50%. (d) Relative ATP levels of normal and tumor cells at different time points after treatment with 2.0 mM VC. (e) H2O2 formation in extracellular fluid with different concentrations of Vc. (f) H2O2 levels of HeLa cells at different concentrations of Vc after treatment with 2.0 mM catalase. (g) EPR spectra showing the radical level produced by MMNCs@PCM@Vc upon AMF application. (h) Schematic illustration of MMNCs@PCM@Vc induced ROS self-generation and self-enhancement behaviour (Fenton reaction-like) in tumor cells. | ||
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| Fig. 7 In vivo biocompatibility evaluation for mice injected with MMNCs@PCM@Vc. Blood biochemical indexes (n = 5) of mice determined on the 1st, 14th and 28th day, respectively. The examined items include (a) aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and glutamyltranspetidase (GGT) concentrations; (b) red blood cell (RBC) counts; (c) white blood cell (WBC) counts; (d) platelet (PLT) counts; (e) hemoglobin (HB) level; (f) albumin (ALB) content; (g) blood urea nitrogen (BUN) level; (h) hematocrit (HCT) level; (i) plateletcrit (PCT) level; (j) mean corpuscular hemoglobin concentration (MCHC) content; (k) mean corpuscular volume (MCV) level; (l) mean corpuscular haemoglobin (MCH) content. (m) Micrographs for the H&E-stained major organ tissues of mice at the 28th day after injection of MMNCs@PCM@Vc, scale bars: 100 μm. | ||
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