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Lewis base-catalyzed diastereoselective [3 + 2] cycloaddition reaction of nitrones with electron-deficient alkenes: an access to isoxazolidine derivatives

Honglei Liua, Yan Zhaoa, Zhen Lia, Hao Jiaa, Cheng Zhanga, Yumei Xiaoa and Hongchao Guo*ab
aDepartment of Applied Chemistry, China Agricultural University, Beijing 100193, China. E-mail: hchguo@cau.edu.cn
bKey Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China

Received 15th April 2017 , Accepted 31st May 2017

First published on 6th June 2017


Abstract

A Lewis base-catalyzed [3 + 2] cycloaddition reaction of nitrones with electron-deficient alkenes has been achieved under mild reaction conditions, affording various functionalized isoxazolidine derivatives as single diastereomers in moderate to excellent yields.


Nucleophilic phosphine-catalyzed cycloaddition reactions provide important access to various synthetically useful or biologically important carbo- and heterocyclic compounds1 and serve as the key step for the total synthesis of some natural products.2 During the past several decades a wide range of cycloaddition reactions have been developed.3–11 A variety of phosphine acceptors such as activated allenes, alkynes and alkenes and electrophilic coupling partners such as aldehydes, alkenes, imines, and aziridines have been exploited for these reactions.1 In the past five years, 1,3-dipoles such as N,N′ or C,N-cyclic azomethine imines and azomethine ylides have been used as versatile electrophilic coupling partners for phosphine-catalyzed [3 + 2],12 [3 + 3],12,13 [4 + 3]12,14 and [3 + 2 + 3]12 cycloadditions with activated allenes, alkynes, alkenes and MBH carbonates, producing biologically important nitrogen-containing heterocycles, such as tetrahydropyrazolopyrazolone, tetrahydropyranzolo-pyridazinone, tetrahydropyrazolodiazepinone, tetrahydropyrazolo-diazocinone, tricyclic dihydroisoquinoline and tetrahydro-isoquinoline derivatives.12–14 Although these dipoles have displayed diverse reactivities in the phosphine-catalyzed cycloadditions, the scope of 1,3-dipoles is still limited to azomethine imines and azomethine ylides. Other kinds of 1,3-dipoles have received little attention and have not been explored in phosphine-catalyzed cycloadditions. In this context, we tried to develop novel cycloaddition reactions based on other 1,3-dipoles, such as nitrones.15 Nitrones are readily accessible and stable compounds and worked as efficient 1,3-dipoles in various cycloadditions to provide diverse cyclic compounds,15 which are important precursors for synthesis of bioactive compounds, natural products and other useful compounds.16 Herein, we present the first phosphine-catalyzed [3 + 2] cycloaddition reaction of various nitrones with electron-deficient alkenes for synthesis of functionalized isoxazolidines, which are potential scaffolds for the synthesis of pharmacologically active molecules (Scheme 1).
image file: c7ra04264g-s1.tif
Scheme 1 Lewis base-catalyzed [3 + 2] cycloaddition of nitrones with electron-deficient alkene.

In our initial investigation, the reaction of N-methyl-1-phenylmethanimine oxide 1a with (Z)-1,2-bis(phenylsulfonyl)-ethylene 2 was chosen as the model reaction (Table 1). The reaction of 1a and 2 was carried out in dichloromethane at room temperature in the absence of catalyst for 48 h, no new spots was observed by TLC monitoring (Table 1, entry 1). In the presence of 20 mol% PPh3, the nitrone 1a was treated with the alkene 2 in dichloromethane at room temperature for 48 h, leading to a desired [3 + 2] cycloaddition product isoxazolidine derivative 3a as a single diastereomer in 99% yield (entry 2). The relative configuration of the product isoxazolidine derivative 3a was unequivocally determined through the related X-ray crystallographic data of the homologous compound 3b in Table 2.17 Several nucleophilic phosphines such as PBu3, Me2PPh, MePPh2, EtPPh2, n-PrPPh2, i-PrPPh2, t-BuPPh2 and CyPPh2 were next screened. Among these phosphines, both Me2PPh and MePPh2 were identified as the most effective catalysts for this reaction (entries 4 and 5). Other phosphines including PBu3, EtPPh2, n-PrPPh2, i-PrPPh2 and CyPPh2 could also promote the reaction, but giving the corresponding product in lower 37–89% yields (entries 3, 6–8, and 10). With the use of t-BuPPh2 as the catalyst, only trace of [3 + 2] cycloaddition product was obtained. Some tertiary amines, such as trimethylamine (Et3N), 1,4-diazobicyclo[2.2.2]octane (DABCO), 1,8-diazabicyclo-[5.4.0]-undec-7-ene (DBU), and 4-dimethylamino-pyridine (DMAP), have also been examined and displayed moderate to excellent catalytic activity (entries 11–14). The DBU and DMAP led to 99% yield of the product 3a (entries 13 and 14). In the presence of Ph3P, the catalyst loading was attempted to be decreased to 10 mol% and 5 mol%, but the yield was reduced to 50% yield and 32% yield, respectively (entries 15 and 16).

Table 1 Screening of the reaction conditionsa

image file: c7ra04264g-u1.tif

Entry Catalyst Yieldb (%)
a Reactions of 1 (0.1 mmol), 2 (0.12 mmol) and catalyst (0.02 mmol) were carried out in 2.5 mL of CH2Cl2 at room temperature for 48 h.b Without catalyst.c 10 mol% catalyst was used.d 5 mol% catalyst was used.
1b 0
2 PPh3 99
3 PBu3 60
4 Me2PPh 95
5 MePPh2 97
6 EtPPh2 77
7 n-PrPPh2 89
8 i-PrPPh2 68
9 t-BuPPh2 Trace
10 CyPPh2 37
11 Et3N 66
12 DABCO 36
13 DBU 99
14 DMAP 99
15c PPh3 50
16d PPh3 32


Table 2 Scope of nitrone 1a

image file: c7ra04264g-u2.tif

Entry Cat. R t/h 3 Yield (%)
a Reactions of 1 (0.2 mmol), 2 (0.24 mmol) and the catalyst (0.04 mmol) were carried out in 5 mL of CH2Cl2 at room temperature.
1 Ph3P C6H5 (1a) 48 3a 99
2 DMAP 2-MeC6H4 (1b) 48 3b 81
3 DMAP 3-MeC6H4 (1c) 48 3c 74
4 DMAP 4-MeC6H4 (1d) 48 3d 69
5 Ph3P 2,4-Me2C6H3 (1e) 48 3e 90
6 Ph3P 3,4-Me2C6H3 (1f) 48 3f 87
7 Ph3P 2-MeOC6H4 (1g) 120 3g 76
8 Ph3P 3-MeOC6H4 (1h) 120 3h 80
9 Ph3P 4-MeOC6H4 (1i) 120 3i 63
10 DMAP 2,3-(OMe)2C6H3 (1j) 120 3j 77
11 Ph3P 2,4-(OMe)2C6H3 (1k) 120 3k 75
12 Ph3P 2,3,4-(OMe)3C6H2 (1l) 120 3l 78
13 Ph3P 4-NMe2C6H4 (1m) 48 3m 65
14 Ph3P 2-FC6H4 (1n) 48 3n 51
15 Ph3P 2-ClC6H4 (1o) 48 3o 91
16 DMAP 3-ClC6H4 (1p) 48 3p 62
17 DMAP 4-ClC6H4 (1q) 48 3q 61
18 Ph3P 2-BrC6H4 (1r) 48 3r 83
19 DMAP 3-BrC6H4 (1s) 48 3s 41
20 Ph3P 4-BrC6H4 (1t) 48 3t 62
21 DMAP 4-PhC6H4 (1u) 48 3u 75
22 Ph3P 2-Naphthyl (1v) 48 3v 99


With the optimal reaction conditions in hand, we next investigated the scope of the Lewis base-catalyzed [3 + 2] cycloaddition of nitrones with alkenes. With 20 mol% of PPh3 or DMAP as the catalyst, various nitrones 1 underwent [3 + 2] cycloaddition reaction with (Z)-1,2-bis(phenylsulfonyl)ethylene 2 in dichloromethane at rt for 48–120 h, providing a variety of 4,5-bis(phenylsulfonyl)isoxazolidine derivatives (3a–3v) in moderate to excellent yields (Table 2, entries 1–22). Nitrones bearing whether electron-donating or withdrawing groups on the benzene ring worked smoothly to afford the corresponding products in satisfactory yields (entries 2–21). The methoxy-substituted nitrones were not very active, requiring longer reaction time (entries 7–12). Those nitrones having di and trisubstituted aryl groups were also tolerated, leading to good yields of the [3 + 2] cycloadducts (entries 5–6, 10–12). Particularly, the cycloaddition of 2-naphthyl-substituted nitrone (1v) proceeded efficiently to give the product 3v in 99% yield (entry 22).

The reaction of nitrone 1a with (E)-1,2-bis(phenylsulfonyl)-ethylene 2′ has also been performed, producing 76% yield of the identical product 3a with the reaction of (Z)-1,2-bis(phenylsulfonyl)-ethylene 2 (Scheme 2). It indicated that the stereoselectivity of the reaction was not influenced by the configuration of carbon–carbon double bond in the alkene 2 and 2′.


image file: c7ra04264g-s2.tif
Scheme 2 PPh3-catalyzed [3 + 2] cycloaddition of nitrone 1a with (E)-1,2-bis(phenylsulfonyl)ethylene 2′.

The proposed mechanism for [3 + 2] cycloaddition of the nitrone 1 with 1,2-bis(phenylsulfonyl)ethylene 2 is presented in Scheme 3. Conjugate addition of the phosphine or tertiary amine to the alkene 2 or 2′ gives the zwitterion intermediate A, which then attacks nitrone 1 to give the intermediate B. It undergoes an intramolecular nucleophilic attack to accomplish the [3 + 2] cyclization to give the product 3 with simultaneous regeneration of the catalyst. Since whether (Z)-alkene 2 or (E)-alkene 2′ produced the identical intermediate A, the stereochemistry of the reaction cannot be influenced by the configuration of the alkene.


image file: c7ra04264g-s3.tif
Scheme 3 Proposed mechanism for the [3 + 2] cycloaddition.

The present reaction is quite robust. The reaction of 0.81 g of nitrone 1e with alkene 2 still worked efficiently to produce the desired product 3e in 78% yield (Scheme 4). To further demonstrate the reaction could be a practical tool for the synthesis of other valuable compounds, some synthetic transformations of cycloadduct 3e were tried (Scheme 4). Treatment of the product 3e with 1 equiv. K2CO3 in THF resulted in elimination of one of two phenylsulfonyl groups, affording the derivative 4 in 73% yield. The oxidation of 3e with 1 equiv. of mCPBA in dichloromethane gave an α,β-unsaturated aldehyde 5 in 67% yield.


image file: c7ra04264g-s4.tif
Scheme 4 Gram-scale synthesis and further transformations of the cycloadduct.

Conclusions

We have developed a Lewis base-catalyzed [3 + 2] cycloaddition reaction of nitrones with electron-deficient alkene, giving various functionalized isoxazolidine derivatives in moderate to excellent yields. A variety of nitrones underwent the reaction smoothly under the mild reaction conditions. The scaled-up reaction and further transformation of the cycloadducts demonstrated that the reaction could be a practical tool for organic synthesis.

Acknowledgements

This work is supported by the NSFC (No. 21172253, 21372256 and 21572264).

Notes and references

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  17. The crystallographic data for 3b has been deposited with the Cambridge Crystallographic Data Centre as supplementary number CCDC 1532199 (see ESI)..

Footnote

Electronic supplementary information (ESI) available: Experimental procedures, spectral data and crystallographic data. CCDC 1532199. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7ra04264g

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