Open Access Article
Steffen V. F.
Hansen
ab,
Zoe E.
Wilson
a,
Trond
Ulven
*b and
Steven V.
Ley
*a
aDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK, svl1000@cam.ac.uk
bDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. E-mail: ulven@sdu.dk
First published on 11th April 2016
Correction for ‘Controlled generation and use of CO in flow’ by Steffen V. F. Hansen et al., React. Chem. Eng., 2016, DOI: 10.1039/c6re00020g.
| # | Iodidea | Product | Yieldb | # | Iodidea | Product | Yieldb | # | Iodidea | Product | Yieldb |
|---|---|---|---|---|---|---|---|---|---|---|---|
a All reactions were carried out on 0.5 mmol scale apart from #8 which was run continuously on 8 mmol scale (320 minutes).
b Isolated yield.
c Methanol was used as the solvent for pump 3, the reaction coil was heated to 25 °C and sample loop filled with iodide 5 (0.1 M), Pd(OAc)2 (0.01 eq.), XantPhos (0.012 eq.), NEt3 (1.5 eq.), H2NNH2 (0.3 eq.) and THF/MeOH (1 : 1).
d Continuous flow reaction.
|
|||||||||||
| 1c |
5
|
6
|
71% | 4 |
11
|
15
|
74% | 7a |
14
|
18
|
79% |
| 2 |
7
|
9
|
97% | 5 |
12
|
16
|
78% | 8d |
7
|
9
|
96% (1.47 g) |
| 3 |
8
|
10
|
99% | 6 |
13
|
17
|
78% | ||||
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| This journal is © The Royal Society of Chemistry 2016 |