DOI:
10.1039/C3RA45312J
(Paper)
RSC Adv., 2014,
4, 5531-5535
Dimethyl homophthalates to naphthopyrans: the total synthesis of arnottin I and the formal synthesis of (−)-arnottin II†
Received
24th September 2013
, Accepted 18th November 2013
First published on 19th November 2013
Abstract
A simple and efficient 3-step synthetic protocol has been reported for dimethyl homophthalates to naphthopyrans. Starting from dimethyl 2,3-dimethoxyhomophthalate, a practical synthesis of arnottin I has been described via a base catalyzed mono-alkylation, the selective hydrolysis of an aliphatic ester moiety, two consecutive intramolecular cyclizations and an oxidative aromatization pathway with a very good overall yield. The involved intramolecular acylation followed by an associated enolative lactonization was the decisive step. The synthesis of dihydroarnottin I also completes the formal synthesis of (−)-arnottin II.
The coumarin-based natural products such as gilvocarcins, ravidomycins, chrysomycins and defucogilvocarcins are an important class of antibiotics.1a–e Analogous arnottin I and the related (−)-arnottin II were isolated as minor components from the bark of Xanthoxylum arnottianum Maxim. (Rutaceae) by Ishikawa and co-workers in 1977.2 They established their structures in 1993 and 1995 on the basis of spectral data and synthesis.3a,b Since then several well-designed synthetic routes involving new carbon–carbon bond forming strategies have been reported for these significant targets.4a–i A careful scrutiny of the arnottins I and II structures and their retrosynthetic analysis revealed that the multifunctional methyl 6-(4-(benzo[d][1,3]dioxol-5-yl)-1-methoxy-1-oxobutan-2-yl)-2,3-dimethoxybenzoate would be a potential precursor to provide convergent access to both the target compounds (Scheme 1). More specifically, the selective intramolecular acylation of the diester followed by a concomitant enolization–lactonization would be the strategic step in generating rings B and C to obtain the desired advanced common intermediate of arnottins I and II. In continuance of our efforts to synthesize structurally interesting and biologically important natural and unnatural products from cyclic anhydrides and their derivatives as the potential precursors,5a–e we herein report a concise and efficient access to naphthopyrans, arnottin I and arnottin II (Scheme 2).
 |
| Scheme 1 The retrosynthetic analysis of arnottins I and II. | |
 |
| Scheme 2 A general approach to naphthopyrans and the total synthesis of arnottin I. | |
Dimethyl homophthalates 1a,b on base promoted alkylation with alkyl iodides 2b,c exclusively furnished the requisite mono-alkylated coupling products 3a–c in 82–85% yields.6a,b The reaction of appropriate precursors 3a,b with methanesulfonic acid at room temperature directly formed the desired double cyclized products 5a,b in nearly quantitative yields (98%) via the corresponding unisolable tetralone intermediates 4a,b. As per the planned strategy, an acid-promoted regioselective intramolecular Friedel–Crafts acylation utilizing an aliphatic ester moiety, the instantaneous enolization of the thus formed tetralone intermediates 4a,b using an acidic α-methine proton and the concurrent δ-lactonization employing a less reactive aromatic ester unit took place in one-pot to deliver the aimed products 5a,b. Compounds 5a,b on treatment with SeO2 in refluxing acetic acid provided the corresponding expected aromatized products 6a,b in 2 h with quantitative yield (98%). The aromatization plausibly took place via a regioselective introduction of an acetate function at the relatively more reactive allylic site followed by its in situ elimination by abstracting the adjacent benzylic proton.7 Thus starting from dimethyl homophthalates we have developed a new practical approach to the naphthopyran systems and it has advantages in terms of number of steps involved and obtained yields.
In the second part of our studies, we planned the synthesis of arnottin I and (−)-arnottin II by using the below defined synthetic protocol. The pivotal arnottin antecedent compound 3c on similar treatment with methanesulfonic acid underwent an unfortunate instantaneous decomposition under the several sets of reaction conditions. We also tried various conditions to effect the transformation of 3c to 5c utilizing reagents such as acetic acid, trifluoroacetic acid and p-TSA, but this always resulted in the isolation of the starting material and/or decomposition. The cause for the decomposition of compound 3c under acidic conditions was the presence of a labile dioxymethylene bridge attached to ring D. To circumvent the above specified difficulty, we initially performed a base catalyzed regioselective mono-hydrolysis of an aliphatic ester moiety in compound 3c and obtained the product 7c in a 91% yield, as the synthesis of the corresponding dicarboxylic acid followed by treatment with dehydrating agents would form the cyclic anhydride and demand sequential synthetic steps to transform compound 3c into the essential product 5c. The acid-ester 7c on treatment with trifluoroacetic anhydride at −50 °C to 25 °C formed a reactive mixed anhydride intermediate and delivered a mixture of the corresponding simple acylation product; the known tetralone intermediate 4c and the desired double cyclized advanced intermediate 5c in quantitative yield4e (∼7
:
3 ratio, by 1H NMR). Herein the second cyclization step was relatively slow due to the mesomeric deactivation of an aromatic ester function by the corresponding ortho-methoxy group. An increase in the reaction temperature and/or extending the reaction time again resulted in some decomposition. The above specified mixture of the tetralone intermediate 4c and compound 5c was silica gel column chromatographically inseparable. Thus to ensure the complete transformation into the essential compound 5c, the above mixture of products was further treated with Cs2CO3 in refluxing toluene (93% yield). Starting from the advanced common intermediate 5c, the synthesis of arnottin I by employing DDQ-oxidation in benzene and the synthesis of (−)-arnottin II via the Sharpless asymmetric dihydroxylative spiro-lactonization route have been known in the literature.4e Similarly, we repeated the DDQ-oxidation of 5c in refluxing toluene and obtained the natural product arnottin I (6c) in a quantitative yield (98%). However, analogous to the 5a,b to 6a,b transformation, the SeO2 oxidation of compound 5c in refluxing acetic acid resulted in the decomposition of the reaction mixture. Alternatively, the performed SeO2 oxidation of compound 5c in refluxing benzene, toluene and freshly distilled acetic anhydride was very slow and provided the silica gel column chromatographically inseparable mixture of the starting material 5c and arnottin I (6c) in 48 h. The 1H NMR spectra of above specified mixtures indicated only 10 to 20% conversions into the desired product 6c. As anticipated, the neat SeO2 (10.00 equiv.) induced oxidative aromatization of dihydronaphthopyran 5c at 200 °C took place in 2 h without any decomposition and provided the desired natural naphthopyran 6c in a 96% yield. The analytical and spectral data obtained for arnottin I was in complete agreement with the reported data.3a,4e Arnottin I was obtained in four steps by using two different oxidizing agents at the ultimate step with 71% and 69% overall yields, respectively.
In summary, we have demonstrated a bio-inspired protection-free concise and efficient total synthesis of arnottin I and the formal synthesis of (−)-arnottin II. The present transition metal free diversity oriented robust 3-step new approach to the imperative naphthopyran architectures is general in nature and will be useful to design several focused mini-libraries of their natural and unnatural analogues and congeners for SAR studies. Our present approach also provides an efficient access to several corresponding isoquinoline alkaloids.6b,8
Experimental section
The melting points are uncorrected. The mass spectra were taken on an MS-TOF mass spectrometer. HRMS (ESI) were taken on an Orbitrap (quadrupole plus ion trap) and TOF mass analyzer. The IR spectra were recorded on an FT-IR spectrometer. The starting materials 1a,b and 2b,c were prepared by using known literature procedures.4h,9 Commercially available chemicals and reagents were used.
Methyl 2-(4-(3,4-dimethoxyphenyl)-1-methoxy-1-oxobutan-2-yl)benzoate (3a)
A fresh solution of LDA was prepared from diisopropylamine (0.87 mL, 6.24 mmol) and n-BuLi (1.60 M in hexane, 4.20 mL, 6.72 mmol) in THF (5 mL) under an argon atmosphere at 0 °C. This was added to a solution of compound 1a (1.00 g, 4.80 mmol) in THF (10 mL) and HMPA (10 mL) mixture at −78 °C under an argon atmosphere and the reaction mixture was further stirred at the same temperature for 30 min. To the above reaction mixture a solution of compound 2b (1.54 g, 5.28 mmol) in THF (5 mL) was added in a dropwise fashion. The reaction mixture was allowed to gradually attain room temperature in 7 h. The reaction was quenched with a saturated NH4Cl solution and the solvent was removed in vacuo. The obtained residue was dissolved in ethyl acetate and the organic layer was washed with water, brine and dried over Na2SO4. The concentration of the organic layer in vacuo followed by silica gel (60–120 mesh) column chromatographic purification of the resulting residue using ethyl acetate–petroleum ether (1
:
3) as an eluent gave the pure product 3a as a thick oil (1.46 g, 82%). 1H NMR (CDCl3, 200 MHz) δ 1.95–2.25 (m, 1H), 2.35–2.70 (m, 3H), 3.68 (s, 3H), 3.87 (s, 6H), 3.88 (s, 3H), 4.64 (t, J = 8 Hz, 1H), 6.69 (s, 1H), 6.72 (t, J = 8 Hz, 1H), 6.78 (t, J = 8 Hz, 1H), 7.27–7.42 (m, 1H), 7.42–7.60 (m, 2H), 7.92 (dd, J = 8, 2 Hz, 1H); 13C NMR (CDCl3, 50 MHz) δ 33.4, 35.2, 46.5, 52.0, 52.1, 55.7, 55.9, 111.1, 111.7, 120.2, 126.9, 128.7, 129.8, 130.7, 132.2, 134.0, 140.2, 147.2, 148.7, 167.8, 174.3; ESIMS (m/z) 395 [M + Na]+; HRMS (ESI) calcd for C21H25O6 373.1646, found 373.1639; IR (CHCl3) νmax 1732, 1721, 1602 cm−1.
The products 3b and 3c were similarly obtained by using the above specified procedure.
Methyl 6-(4-(3,4-dimethoxyphenyl)-1-methoxy-1-oxobutan-2-yl)-2,3-dimethoxybenzoate (3b)
Thick oil (1.33 g, 83%); 1H NMR (CDCl3, 200 MHz) δ 1.90–2.15 (m, 1H), 2.25–2.68 (m, 3H), 3.55 (t, J = 8 Hz, 1H), 3.67 (s, 3H), 3.82 (s, 3H), 3.85 (s, 6H), 3.86 (s, 3H), 3.88 (s, 3H), 6.62–6.74 (m, 2H), 6.79 (d, J = 8 Hz, 1H), 6.94 (d, J = 8 Hz, 1H), 7.15 (d, J = 8 Hz, 1H); 13C NMR (CDCl3, 50 MHz) δ 33.2, 35.3, 46.5, 52.0, 52.1, 55.7, 55.8 (2C), 61.4, 111.1, 111.6, 113.7, 120.2, 123.1, 128.3, 129.4, 133.7, 145.8, 147.1, 148.7, 151.5, 167.5, 173.9; ESIMS (m/z) 455 [M + Na]+; HRMS (ESI) calcd for C23H29O8 433.1857, found 433.1851; IR (CHCl3) νmax 1735, 1610 cm−1.
Methyl 6-(4-(benzo[d][1,3]dioxol-5-yl)-1-methoxy-1-oxobutan-2-yl)-2,3-dimethoxybenzoate (3c)
Thick oil (1.32 g, 85%); 1H NMR (CDCl3, 200 MHz) δ 1.65–2.10 (m, 1H), 2.20–2.65 (m, 3H), 3.54 (t, J = 8 Hz, 1H), 3.65 (s, 3H), 3.85 (s, 9H), 5.89 (s, 2H), 6.58 (dd, J = 8, 2 Hz, 1H), 6.64 (d, J = 2 Hz, 1H), 6.71 (d, J = 8 Hz, 1H), 6.94 (d, J = 10 Hz, 1H), 7.13 (d, J = 10 Hz, 1H); 13C NMR (CDCl3, 50 MHz) δ 33.3, 35.3, 46.5, 51.9, 52.1, 55.8, 61.4, 100.6, 108.0, 108.8, 113.8, 121.1, 123.1, 128.2, 129.4, 135.0, 145.6, 145.8, 147.4, 151.5, 167.5, 173.8; ESIMS (m/z) 439 [M + Na]+; HRMS (ESI) calcd for C22H25O8 417.1544, found 417.1537; IR (CHCl3) νmax 1733, 1604 cm−1.
2,3-Dimethoxy-11,12-dihydro-6H-dibenzo[c,h]chromen-6-one (5a)
To compound 3a (372 mg, 1.00 mmol) CH3SO3H (4 mL) was added at room temperature under an argon atmosphere and the reaction mixture was stirred for 30 min. The reaction mixture was poured on crushed ice and the obtained precipitate was filtered, washed with water and 10% aqueous NaHCO3 and dried using a vacuum pump. The silica gel (60–120 mesh) column chromatographic purification of the resulting compound using ethyl acetate–petroleum ether (3
:
7) as an eluent gave the pure product 5a as a yellow solid (302 mg, 98%). Mp 167–169 °C (ref. 10, 105 °C); 1H NMR (CDCl3, 400 MHz) δ 2.85–3.00 (m, 4H), 3.92 (s, 3H), 3.96 (s, 3H), 6.75 (s, 1H), 7.38 (s, 1H), 7.45 (t, J = 8 Hz, 1H), 7.57 (d, J = 8 Hz, 1H), 7.75 (t, J = 8 Hz, 1H), 8.33 (d, J = 8 Hz, 1H); 13C NMR (CDCl3, 100 MHz) δ 21.2, 26.9, 56.0, 56.3, 106.1, 107.6, 110.9, 120.4, 121.3, 121.8, 127.1, 129.7, 130.2, 134.7, 137.6, 148.0, 148.3, 149.8, 162.3; ESIMS (m/z) 331 [M + Na]+; IR (CHCl3) νmax 1733, 1722, 1631, 1603 cm−1.
The product 5b was similarly obtained by using the above specified procedure.
2,3,7,8-Tetramethoxy-11,12-dihydro-6H-dibenzo[c,h]chromen-6-one (5b)
Yellow solid (360 mg, 98%); mp 172–174 °C (ref. 11, 171–172 °C); 1H NMR (CDCl3, 200 MHz) δ 2.80–3.02 (m, 4H), 3.93 (s, 3H), 3.96 (s, 3H), 3.98 (s, 3H), 4.00 (s, 3H), 6.75 (s, 1H), 7.30 (d, J = 10 Hz, 1H), 7.38 (s, 1H), 7.39 (d, J = 10 Hz, 1H); 13C NMR (CDCl3, 50 MHz) δ 21.6, 27.0, 56.0, 56.3, 56.6, 61.5, 105.8, 106.9, 110.9, 115.0, 117.7, 119.9, 121.3, 129.1, 132.2, 146.6, 147.9, 149.3, 151.5, 152.1, 158.7; ESIMS (m/z) 391 [M + Na]+; IR (CHCl3) νmax 1730 cm−1.
2,3-Dimethoxy-6H-dibenzo[c,h]chromen-6-one (6a)
To a stirred solution of compound 5a (154 mg, 0.50 mmol) in AcOH (5 mL) SeO2 (165 mg, 1.50 mmol) was added and the reaction mixture was refluxed for 2 h under an argon atmosphere. It was allowed to reach room temperature and was concentrated in vacuo. The obtained residue was dissolved in ethyl acetate (20 mL) and the organic layer was washed with water, a saturated solution of NaHCO3 and brine and dried over Na2SO4. The concentration of the organic layer in vacuo followed by the silica gel (60–120 mesh) column chromatographic purification of the resulting residue using ethyl acetate–petroleum ether (3
:
7) as an eluent gave the pure product 6a as a faint yellow solid (150 mg, 98%). Mp 217–220 °C (ref. 10, 213 °C); 1H NMR (CDCl3, 200 MHz) δ 4.02 (s, 3H), 4.09 (s, 3H), 7.10 (s, 1H), 7.54 (t, J = 8 Hz, 1H), 7.56 (d, J = 8 Hz, 1H), 7.74 (s, 1H), 7.82 (dt, J = 8, 2 Hz, 2H), 7.87 (d, J = 10 Hz, 1H), 8.11 (d, J = 10 Hz, 1H), 8.41 (d, J = 8 Hz, 1H); 13C NMR (CDCl3, 50 MHz) δ 55.8, 56.2, 100.7, 106.1, 111.5, 117.2, 118.6, 120.3, 121.5, 122.6, 127.8, 130.1, 130.2, 134.6, 135.4, 146.0, 149.9, 150.5, 161.2; ESIMS (m/z) 306 [M]+; IR (CHCl3) νmax 1732, 1629, 1607 cm−1.
The product 6b was similarly obtained by using the above specified procedure.
2,3,7,8-Tetramethoxy-6H-dibenzo[c,h]chromen-6-one (6b)
Faint yellow solid (179 mg, 98%); mp 230–232 °C (ref. 12, 218–220 °C); 1H NMR (CDCl3, 200 MHz) δ 4.00 (s, 3H), 4.05 (s, 6H), 4.12 (s, 3H), 7.15 (s, 1H), 7.46 (d, J = 8 Hz, 1H), 7.58 (d, J = 8 Hz, 1H), 7.80 (s, 1H), 7.86 (d, J = 8 Hz, 1H), 7.91 (d, J = 8 Hz, 1H); 13C NMR (CDCl3, 125 MHz) δ 55.9, 56.3, 56.4, 61.5, 100.9, 106.3, 111.5, 115.1, 117.4, 117.7, 118.6, 119.5, 122.5, 129.70, 129.74, 145.4, 150.0, 150.4, 151.5, 152.8, 157.9; ESIMS (m/z) 389 [M + Na]+; IR (CHCl3) νmax 1735, 1633 cm−1.
4-(Benzo[d][1,3]dioxol-5-yl)-2-(3,4-dimethoxy-2-(methoxycarbonyl)phenyl)butanoic acid (7c)
To a stirred solution of compound 3c (1.25 g, 3.00 mmol) in MeOH (25 mL) 2% aqueous KOH (25 mL) was added at 0 °C. The reaction mixture was allowed to gradually attain room temperature and was further stirred for 24 h. It was acidified with 2 N HCl and the formed product was extracted in ethyl acetate (25 mL × 2). The organic layer was washed with water and brine and dried over Na2SO4. The concentration of the organic layer in vacuo followed by the silica gel (60–120 mesh) column chromatographic purification of the resulting residue using ethyl acetate–petroleum ether (4
:
6) as an eluent gave the pure product 7c as a thick oil (1.10 g, 91%). 1H NMR (CDCl3, 200 MHz) δ 1.90–2.15 (m, 1H), 2.20–2.60 (m, 3H), 3.52 (t, J = 8 Hz, 1H), 3.86 (s, 9H), 5.89 (s, 2H), 6.57 (dd, J = 8, 2 Hz, 1H), 6.62 (d, J = 2 Hz, 1H), 6.70 (d, J = 8 Hz, 1H), 6.96 (d, J = 10 Hz, 1H), 7.14 (d, J = 8 Hz, 1H); 13C NMR (CDCl3, 50 MHz) δ 33.1, 34.5, 46.4, 52.4, 55.9, 61.4, 100.7, 108.1, 108.9, 114.2, 121.2, 123.2, 127.7, 129.3, 134.8, 145.7, 146.1, 147.5, 151.8, 168.2, 177.9; ESIMS (m/z) 425 [M + Na]+; HRMS (ESI) calcd for C21H22O8Na 425.1207, found 425.1204; IR (CHCl3) νmax 2700–2500, 1731, 1709, 1606 cm−1.
1,2-Dimethoxy-13H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-h]benzo[c]chromen-13-one (5c)
To compound 7c (200 mg, 0.49 mmol) TFAA (2 mL) was added at −50 °C and the reaction mixture was stirred under an argon atmosphere at −50 °C to 25 °C for 3 h. The reaction mixture was concentrated in vacuo and the obtained residue was dried using a vacuum pump. To the residue toluene (5 mL) and Cs2CO3 (326 mg, 1.00 mmol) were added, and the stirred reaction mixture was refluxed for 2 h. It was allowed to reach room temperature and was concentrated in vacuo. The obtained residue was dissolved in ethyl acetate (30 mL) and the organic layer was washed with water and brine and dried over Na2SO4. The concentration of the organic layer in vacuo followed by the silica gel (60–120 mesh) column chromatographic purification of the resulting residue using ethyl acetate–petroleum ether (3
:
7) as an eluent gave the pure product 5c as a yellow solid (162 mg, 93%). Mp 245–248 °C (ref. 4e, 250–251 °C); 1H NMR (CDCl3, 500 MHz) δ 2.81 (dd, J = 10, 2 Hz, 1H), 2.82 (d, J = 10 Hz, 1H), 2.91 (d, J = 10 Hz, 1H), 2.92 (dd, J = 10, 2 Hz, 1H), 3.95 (s, 3H), 3.99 (s, 3H), 5.97 (s, 2H), 6.70 (s, 1H), 7.28 (d, J = 10 Hz, 1H), 7.35 (s, 1H), 7.36 (d, J = 10 Hz, 1H); 13C NMR (CDCl3, 125 MHz) δ 21.6, 27.6, 56.6, 61.5, 101.2, 103.5, 107.1, 108.3, 115.2, 117.8, 119.9, 122.7, 130.8, 132.1, 146.6, 146.7, 147.9, 151.6, 152.2, 158.5; ESIMS (m/z) 375 [M + Na]+; IR (CHCl3) νmax 1734, 1700, 1670 cm−1.
1,2-Dimethoxy-13H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-h]benzo[c]chromen-13-one (arnottin I, 6c)
A neat mixture of compound 5c (70 mg, 0.20 mmol) and SeO2 (220 mg, 2.00 mmol) was heated in the sealed tube at 200 °C for 2 h. It was allowed to reach room temperature and the obtained residue was dissolved in ethyl acetate (20 mL). The organic layer was washed with water, a saturated solution of NaHCO3 and brine and dried over Na2SO4. The concentration of the organic layer in vacuo provided the pure product 6c as a yellow solid (67 mg, 96%). The analytically pure sample of 6c was obtained by recrystallization from chloroform. Mp 296–298 °C (ref. 3a, 293–297 °C); 1H NMR (CDCl3, 200 MHz) δ 4.00 (s, 3H), 4.04 (s, 3H), 6.11 (s, 2H), 7.15 (s, 1H), 7.46 (d, J = 10 Hz, 1H), 7.55 (d, J = 10 Hz, 1H), 7.86 (d, J = 10 Hz, 1H), 7.86 (s, 1H), 7.90 (d, J = 10 Hz, 1H); 13C NMR (CDCl3, 125 MHz) δ 56.6, 61.6, 99.1, 101.5, 104.0, 112.1, 115.5, 117.7, 117.8, 119.7, 120.2, 123.2, 129.8, 131.2, 146.1, 148.5, 148.9, 151.7, 153.1, 157.7; ESIMS (m/z) 373 [M + Na]+; IR (CHCl3) νmax 1734,1651 cm−1.
Acknowledgements
R. J. thanks CSIR, New Delhi, for the award of research fellowship. N. P. A. thanks the Department of Science and Technology, New Delhi for financial support.
References
-
(a) P. R. Nandaluru and G. J. Bodwell, J. Org. Chem., 2012, 77, 8028 CrossRef CAS PubMed;
(b) I. Hussain, V. T. H. Nguyen, M. A. Yawer, T. T. Dang, C. Fischer, H. Reinke and P. Langer, J. Org. Chem., 2007, 72, 6255 CrossRef CAS PubMed;
(c) D. K. Rayabarapu, P. Shukla and C.-H. Cheng, Org. Lett., 2003, 5, 4903 CrossRef CAS PubMed;
(d) D. H. Hua, S. Saha, D. Roche, J. C. Maeng, S. Iguchi and C. Baldwin, J. Org. Chem., 1992, 57, 399 CrossRef CAS;
(e) U. Hacksell and G. D. Daves Jr, Prog. Med. Chem., 1985, 22, 1 CrossRef CAS , and references cited therein 1a–e.
- H. Ishii, T. Ishikawa and J. Haginiwa, Yakugaku Zasshi, 1977, 97, 890 CAS.
-
(a) H. Ishii, T. Ishikawa, M. Murota, Y. Aoki and T. Harayama, J. Chem. Soc., Perkin Trans. 1, 1993, 1019 RSC;
(b) T. Ishikawa, M. Murota, T. Watanabe, T. Harayama and H. Ishii, Tetrahedron Lett., 1995, 36, 4269 CrossRef CAS.
-
(a) T. Harayama and H. Yasuda, Heterocycles, 1997, 46, 61 CrossRef CAS PubMed;
(b) T. Ishikawa, K. Hino, T. Yoneda, M. Murota, K. Yamaguchi and T. Watanabe, J. Org. Chem., 1999, 64, 5691 CrossRef CAS;
(c) T. Harayama, H. Yasuda, T. Akiyama, Y. Takeuchi and H. Abe, Chem. Pharm. Bull., 2000, 48, 861 CrossRef CAS;
(d) S. Madan and C.-H. Cheng, J. Org. Chem., 2006, 71, 8312 CrossRef CAS PubMed;
(e) F. Konno, T. Ishikawa, M. Kawahata and K. Yamaguchi, J. Org. Chem., 2006, 71, 9818 CrossRef CAS PubMed;
(f) C. A. James and V. Snieckus, J. Org. Chem., 2009, 74, 4080 CrossRef CAS PubMed;
(g) C. A. James, A. L. Coelho, M. Gevaert, P. Forgione and V. Snieckus, J. Org. Chem., 2009, 74, 4094 CrossRef CAS PubMed;
(h) D. Mal, A. K. Jana, P. Mitra and K. Ghosh, J. Org. Chem., 2011, 76, 3392 CrossRef CAS PubMed;
(i) I. R. Pottie, P. R. Nandaluru, W. L. Benoit, D. O. Miller, L. N. Dawe and G. J. Bodwell, J. Org. Chem., 2011, 76, 9015 CrossRef CAS PubMed.
-
(a) P. Mondal and N. P. Argade, J. Org. Chem., 2013, 78, 6802 CrossRef CAS PubMed;
(b) R. M. Patel and N. P. Argade, Org. Lett., 2013, 15, 14 CrossRef CAS PubMed;
(c) P. S. Deore and N. P. Argade, J. Org. Chem., 2012, 77, 739 CrossRef CAS PubMed;
(d) U. A. Kshirsagar, V. G. Puranik and N. P. Argade, J. Org. Chem., 2010, 75, 2702 CrossRef CAS PubMed;
(e) P. B. Wakchaure, S. Easwar, V. G. Puranik and N. P. Argade, Tetrahedron, 2008, 64, 1786 CrossRef CAS PubMed.
-
(a) R. Okunaka, T. Honda, M. Kondo, Y. Tamura and Y. Kita, Chem. Pharm. Bull., 1991, 39, 1298 CrossRef CAS;
(b) R. Jangir and N. P. Argade, RSC Adv., 2012, 2, 7087 RSC.
- P. C. Bulman Page and T. J. McCarthy, in Comprehensive Organic Synthesis, ed. B. M. Trost and I. Fleming, Pergamon Press, Oxford, 1991, vol. 7, p. 83 Search PubMed.
- R. P. Korivi and C.-H. Cheng, Chem.–Eur. J., 2010, 16, 282 CrossRef CAS PubMed.
- S. Shahane, F. Louafi, J. Moreau, J.-P. Hurvois, J.-L. Renaud, P. V. D. Weghe and T. Roisnel, Eur. J. Org. Chem., 2008, 4622 CrossRef CAS.
- J. N. Chatterjea, S. C. Bhakta and A. K. Chattopadhyay, J. Indian Chem. Soc., 1974, LI, 757 Search PubMed.
- A. S. Bailey and C. R. Worthing, J. Chem. Soc., 1956, 4535 RSC.
- E. Martínez, L. Martínez, M. Treus, J. C. Estévez, R. J. Estévez and L. Castedo, Tetrahedron, 2000, 56, 6023 CrossRef.
Footnote |
† Electronic supplementary information (ESI) available. See DOI: 10.1039/c3ra45312j |
|
This journal is © The Royal Society of Chemistry 2014 |
Click here to see how this site uses Cookies. View our privacy policy here.