Themed collection Biomaterials Science Recent HOT Articles
Nanoscale metal–organic frameworks for the intracellular delivery of CRISPR/Cas9 genome editing machinery
The discovery of CRISPR/Cas9 genome-editing technology enables the precise manipulation of mammalian DNA sequences for treating genetic disorders.
Application and research progress of phase change materials in biomedical field
Application of phase change materials (PCMs) in biomedical field.
In situ self-assembled peptide nanofibers for cancer theranostics
Nanofibers constructed by an in situ self-assembly strategy hold tremendous promise for cancer theranostics with characteristic functions and biological effects in different parts of tumor tissue.
Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity
Stimuli-responsive in situ self-assembly of small molecule probes into nanostructures has been promising for the construction of molecular probes for in vivo imaging.
Recent developments in mussel-inspired materials for biomedical applications
Over the decades, researchers have strived to synthesize and modify nature-inspired biomaterials, with the primary aim to address the challenges of designing functional biomaterials for regenerative medicine and tissue engineering.
Deoxyribonucleic acid anchored on cell membranes for biomedical application
This review provides an overview of engineering cellular membranes with deoxyribonucleic acids to manipulate cellular behaviors and functionalities for biomedical applications. The current challenges and future directions are summarized and proposed.
Marine origin materials on biomaterials and advanced therapies to cartilage tissue engineering and regenerative medicine
This comprehensive review brings a larger perspective on the most recent developments in new tissue-scaffolds based on marine origin polymers envisaging the treatment and repair of human articular cartilage tissues.
Recent progress in nanotechnology-based drug carriers for celastrol delivery
Various types of celastrol nanoformulations have been developed to treat a number of disorders, including cancer, inflammatory, auto-immune, obesity.
Recent advances in covalent organic frameworks for cancer diagnosis and therapy
Emerging opportunities and challenges of covalent organic frameworks (COFs) in cancer diagnosis and therapy are summarized. The future research directions of COF-based nanoplatforms for cancer theranostics are presented.
Fascinating MXene nanomaterials: emerging opportunities in the biomedical field
In recent years, there has been rapid progress in MXene research due to its distinctive two-dimensional structure and outstanding properties.
Molecular engineering of antimicrobial peptide (AMP)–polymer conjugates
Engineering the architectures of antimicrobial peptide-polymer conjugates provides compelling opportunities to balance bactericidal activity with stability and biocompatibility, to address the critical need for innovative antimicrobial treatments.
Necessity of regulatory guidelines for the development of amyloid based biomaterials
The recent surge in amyloid-based biomaterial development needs regulatory guidelines and safety assessment to avoid adverse health effects.
Peptide-based supramolecular hydrogels for bioimaging applications
Peptide-based supramolecular hydrogels have unique merits in bioimaging applications.
Recent advances in semiconducting polymer dots as optical probes for biosensing
This review mainly summarized the recent results that used bright polymer dots (Pdots) for the detection of different analytes such as reactive oxygen species (ROS), metal ions, pH values, and a variety of biomolecules.
The development of phosphorescent probes for in vitro and in vivo bioimaging
This review mainly introduces the phosphorescent probes applied in vitro and in vivo bioimaging.
Photothermal bactericidal surfaces: killing bacteria using light instead of biocides
Recent developments of photothermal bactericidal surfaces based on immobilized photothermal agents to kill bacteria through hyperthermia effects are reviewed.
Biomaterials-based approaches to model embryogenesis
Biomaterials are emerging as invaluable tools to investigate key mechanisms of human development using advance in vitro models. Nanomaterials can contribute to further refine these models.
Single-atom nanozymes for biological applications
Single-atom nanozymes with high catalytic activity, selectivity, and stability have been used in the treatment of cancer, wound trauma, and brain diseases.
Structured micro/nano materials synthesized via electrospray: a review
Electrospray enables the preparation of versatile spherical, non-spherical, and assembled micro/nano materials.
A call for action to the biomaterial community to tackle antimicrobial resistance
The global surge of antimicrobial resistance (AMR) is a major concern for public health and proving to be a key challenge in modern disease treatment, requiring action plans at all levels.
Polydopamine free radical scavengers
This feature article summarizes the recent progress, challenges and future directions of free radical scavengers based on polydopamine, including the integrated mechanism, current regulating strategies, and kinds of biomedical applications.
Hemostatic nanotechnologies for external and internal hemorrhage management
Hemostatic nanotechnologies promote the development of various hemostatic materials for external and internal hemorrhage management.
Recent advances in improving tumor-targeted delivery of imaging nanoprobes
This review discusses various recent strategies based on different targeting ligands to improve the tumor-specific targeting of nanoprobes toward precision imaging diagnosis.
Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22
Interleukin (IL)-22 is a multifunctional cytokine with a very short half-life that activates STAT3 and can elicit an anti-inflammatory response. We show encapsulation of IL-22 in LPMSN enhances its biological activity and stability in in vitro and human colonic organoids.
Non-contact measurement of internal body temperature using subcutaneously implanted diamond microparticles
We demonstrate the feasibility of subcutaneously implanted fluorescent diamond microparticles as a temperature probe for the non-contact measurement of internal body temperature using a homemade wide-field optically detected magnetic resonance imager.
3D printing of lubricative stiff supramolecular polymer hydrogels for meniscus replacement
Thickening a concentrated solution of a multiple-H-bonding monomer (MHM) and a zwitterion monomer (ZM) with a soft poly(MHM-co-ZM) gel enables direct printing of the MHM, and post-polymerization generates a stiff and lubricative hydrogel meniscus.
Isolation and characterization of porcine macrophages and their inflammatory and fusion responses in different stiffness environments
Evaluating the host immune response to biomaterials is an essential step in the development of medical devices and tissue engineering strategies.
A tripartite carbohydrate-binding module to functionalize cellulose nanocrystals
mSA-CBM3-AzF is a chimeric protein targeting cellulose nanocrystals (CNCs) with high affinity. It presents two additional domains providing a wide choice of chemical and biological molecules to functionalize CNCs.
Improved epithelial cell–cell adhesion using molecular mobility of supramolecular surfaces
The role of molecular mobility on polyrotaxane surfaces was investigated in epithelial cell–cell adhesion. The polyrotaxane surfaces with higher mobility induced cytoplasmic YAP localization, leading to stronger cell–cell adhesion.
The in vivo fate of tobacco mosaic virus nanoparticle theranostic agents modified by the addition of a polydopamine coat
The coating of tobacco mosaic virus (TMV) nanoparticles Gd-Cy5-TMV with polydopamine (PDA) increased protein corona formation and shortened plasma circulation, but minimized recognition by anti-TMV antibodies, and extended organ distribution/clearance.
A multifunctional green antibacterial rapid hemostasis composite wound dressing for wound healing
A green multifunctional wound dressing with low-cost that can accelerate wound healing in comparison to gauze.
Dual-sensitive dual-prodrug nanoparticles with light-controlled endo/lysosomal escape for synergistic photoactivated chemotherapy
The dual-sensitive dual-prodrug nanoparticles (DDNPs) with light-controlled drug-release on demand and endo/lysosomal escape for synergistic photoactivated chemotherapy.
Interrogating cardiac muscle cell mechanobiology on stiffness gradient hydrogels
Mechanobiology of H9C2 cells and neonatal cardiomyocytes mapped using stiffness gradient hydrogels with a range of extracellular matrix coatings, revealing stiffness-driven trends in cell morphology, YAP and MRTF-A expression.
A facile method for high-throughput screening of drug-eluting coatings in droplet microarrays based on ultrasonic spray deposition
Droplet microarrays are fabricated for the high-throughput screening of drug-eluting coatings via ultrasonic spray deposition technique.
Microneedle-mediated delivery of MIL-100(Fe) as a tumor microenvironment-responsive biodegradable nanoplatform for O2-evolving chemophototherapy
MIL-100(Fe) nanoparticles integrated microneedles were employed to codeliver the hydrophobic photosensitizer zinc phthalocyanine (ZnPc) and the chemotherapeutical drug doxorubicin hydrochlorate (Dox) (Z/D@MOF) for O2-evolving chemophototherapy.
c-Met-targeted near-infrared fluorescent probe for real-time depiction and dissection of perineural invasion and lymph node metastasis lesions in pancreatic ductal adenocarcinoma xenograft models
c-Met-targeted near-infrared fluorescent probe has excellent targeting ability to pancreatic ductal adenocarcinoma (PDAC), and can be used for real-time detection of lymph node metastasis and perineural invasion lesions in PDAC xenograft models.
Pre-shear bioprinting of highly oriented porous hydrogel microfibers to construct anisotropic tissues
A pre-shear bioprinting strategy of oriented porous cell-laden hydrogel microfiber to construct anisotropic tissues is first proposed. Different cells encapsulated in the oriented microfibers exhibit oriented growth behaviors similar to that in vivo.
Hydrophilic hindering and hydrophobic growing: a vesicle glycometabolism multi-drug combination therapeutic against Alzheimer's disease
Advanced drug vehicle exploitation and the sophisticated synergy mechanism revelation are two great difficulties in combination therapy.
A sulfonate-based polypeptide toward infection-resistant coatings
We developed a mono-component and sulfonate-based polypeptide coating with reversible on-demand bactericidal and antifouling properties.
High-stability NIR-II fluorescence polymer synthesized by atom transfer radical polymerization for application in high-resolution NIR-II imaging
This article reports a high-stability NIR-II fluorescence polymer synthesized by atom transfer radical polymerization for application in high-resolution NIR-II imaging.
Enhanced anti-tumor efficacy by inhibiting HIF-1α to reprogram TAMs via core-satellite upconverting nanoparticles with curcumin mediated photodynamic therapy
Cur–CSNPs mediated PDT suppress TNBC through the synergistic immunotherapeutic effects by suppressing the expression of HIF-1α to reprogram the pro-tumor TAM2 into the anti-tumor TAM1.
Plasmonic enhanced enzyme activity by catalytic cascade induced mutual benefit tumor starvation/immune/photothermal therapy
Single tumor starvation therapy can activate other signaling pathways in tumor cells and easily induce tumor cell metastasis.
Dual-sonosensitizer loaded phase-transition nanoparticles with tumor-targeting for synergistically enhanced sonodynamic therapy
Sonodynamic therapy (SDT) is a fast-growing therapy activated by using ultrasound to initiate a catalytic reaction of sensitizing agents and kill tumor cells through producing reactive oxygen species (ROS).
Black phosphorus assisted polyionic micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumors
An illustration of black phosphorus (BP) assisted polyionic mPEG-PDMATC micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumors.
Vitamin E-facilitated carbon monoxide pro-drug nanomedicine for efficient light-responsive combination cancer therapy
A reliable approach is developed to formulate a targeted lipid-coated nanomedicine based on UCNP and co-loaded with CO-prodrug and vitamin E, which can convert NIR light to UV photon to release CO for synergistical cancer therapy with vitamin E.
Triple-target stimuli-responsive anti-COVID-19 face mask with physiological virus-inactivating agents
The SARS-CoV-2 infection is transmitted by respiratory droplets. We have introduced a new concept of masks, which comprises a threefold mode-of-action: trapping of the virus particles, blocking of the viruses, and finally killing of the viruses.
A pH-triggered fluorescence-switchable extracellular vesicle for tracing drug release and improving drug delivery
A pH-triggered fluorescence-switchable extracellular vesicle is developed by loading zwitterionic fluorescent carbon dots into macrophage cell-secreted vesicles, which enables to improve drug delivery and monitor drug release in real time.
Synthesis of a zwitterionic N-Ser–Ser-C dimethacrylate cross-linker and evaluation in polyampholyte hydrogels
Polyampholyte hydrogels are attractive materials for tissue engineering scaffolds as they offer a wide variety of features including nonfouling, selective protein delivery, and tunable physical characteristics.
FeSe2 nanosheets as a bifunctional platform for synergistic tumor therapy reinforced by NIR-II light
FeSe2 nanosheets, relying on their inherent NIR-II-mediated photothermal property and photothermal-enhanced photodynamic performance, provide a new paradigm for the design of advanced drug carriers.
Asiaticoside-laden silk nanofiber hydrogels to regulate inflammation and angiogenesis for scarless skin regeneration
Asiaticoside-laden silk nanofiber hydrogels regulated inflammation and angiogenesis dynamically in the inflammation and remodeling states, achieving scarless skin regeneration.
Biological sealing and integration of a fibrinogen-modified titanium alloy with soft and hard tissues in a rat model
A Ti–6Al–4V alloy was modified with fibrinogen as mediated by polydopamine, and the skin-implant interface was examined after transcutaneous implantation. The surface modification could inhibit epithelial downgrowth and promote bone regeneration.
A light and hypoxia-activated nanodrug for cascade photodynamic-chemo cancer therapy
A pH-sensitive polymeric nanovesicle is prepared to co-encapsulate Ce6 and tirapazamine (TPZ) as a light and hypoxia-activated nanodrug for highly efficient photodynamic-chemo cancer therapy.
Cascade targeting tumor mitochondria with CuS nanoparticles for enhanced photothermal therapy in the second near-infrared window
A cascade targeting design enables CuS nanoparticles to specifically target tumor mitochondria, achieving significantly improved efficacy of NIR-II photothermal therapy.
Enhanced NO-induced angiogenesis via NO/H2S co-delivery from self-assembled nanoparticles
The simultaneous delivery of NO and H2S from prepared self-assembled polymeric nanoparticles shows advantages of a controlled release concentration and improved angiogenic properties in vitro and ex vivo by a synergistic effect.
A flexible microfluidic strategy to generate grooved microfibers for guiding cell alignment
A flexible microfluidic strategy to generate grooved microfibers relies on in situ gelling of different concentrations of alginate as anisotropic scaffolds for guiding cell alignment.
A new near-infrared phosphorescent iridium(III) complex conjugated to a xanthene dye for mitochondria-targeted photodynamic therapy
A novel near-infrared phosphorescent iridium(III) complex was developed for cell mitochondria-targeted imaging and photodynamic therapy in vivo.
Cytosolic protein delivery via metabolic glycoengineering and bioorthogonal click reactions
Carrier-free cytosolic protein delivery was achieved via metabolic glycoengineering and bioorthogonal click reactions.
Oxygen-carrying nanoparticle-based chemo-sonodynamic therapy for tumor suppression and autoimmunity activation
DTX/CS–Rh–PFC nanoparticles are hydrolyzed by glutathione in tumor cells, releasing DTX and oxygen molecules, and thus exhibit good anti-tumor ability.
The effects of VEGF-centered biomimetic delivery of growth factors on bone regeneration
The Biomimetic group was prepared by combining MP particles, LSS particles, and pluornic mixture-infiltrated LSS particles. The Biomimetic group resulted in faster bone regeneration than the Continuous group, unlike the in vitro observations.
Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells
Mesenchymal stem cells on polyrotaxane surfaces underwent enhanced osteoblast and adipocyte differentiation. Two independent parameters, high molecular mobility and negative charge on the surfaces, may not offset the effect to promote both differentiation.
Sulfoxide-functionalized nanogels inspired by the skin penetration properties of DMSO
Sulfoxide-functionalized nanogels show a high potential to effectively emulate the skin penetration enhancing properties of DMSO without its negative side effects.
Near-infrared light-triggered nanobomb for in situ on-demand maximization of photothermal/photodynamic efficacy for cancer therapy
A novel near-infrared light-responsive nanobomb was developed to overcome the aggregation issues of PTT/PDT agents and fundamentally improve the synergistic efficacy in cancer therapy.
Theranostic supramolecular polymers formed by the self-assembly of a metal-chelating prodrug
The direct linkage of two camptothecin moieties to a metal chelator creates a self-assembling prodrug capable of associating in aqueous solution into theranostic supramolecular polymers.
Novel anilino quinazoline-based EGFR tyrosine kinase inhibitors for treatment of non-small cell lung cancer
The two novel anilino quinazoline-based EGFR-TKIs have promising anti-tumor activity and limited hepatotoxicity, representing excellent candidates for combating the NSCLC.
Green facile synthesis to develop nanoscale coordination polymers as lysosome-targetable luminescent bioprobes
A facile green hand grinding technique has been adopted towards the design of three nanoscale crystalline materials that serves as an excellent selective bio tracker for intracellular lysosome.
An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance
An α/β chimeric polypeptide molecular brush shows excellent performance in eradicating established biofilms, persister cells, and clinically isolated multi-drug resistant Gram-positive bacteria.
Cascaded bio-responsive delivery of eNOS gene and ZNF580 gene to collaboratively treat hindlimb ischemia via pro-angiogenesis and anti-inflammation
The cascaded, bio-responsively delivered eNOS gene and ZNF580 gene overcome transfection bottlenecks and collaboratively exert anti-ischemic function via promoting angiogenesis and alleviating inflammation.
Fe-TCPP@CS nanoparticles as photodynamic and photothermal agents for efficient antimicrobial therapy
Photodynamic and photothermal agents for efficient antimicrobial therapy.
Increased cross-linking micelle retention in the brain of Alzheimer's disease mice by elevated asparagine endopeptidase protease responsive aggregation
The asparagine endopeptidase responsive cross-linking micelle (RCM) increased the brain retention of Alzheimer's disease mice.
Ultra-small platinum nanoparticles on gold nanorods induced intracellular ROS fluctuation to drive megakaryocytic differentiation of leukemia cells
Au@Pt nanoparticles induce chronic myeloid leukemia cells to differentiate into megakaryocytes by causing intracellular ROS fluctuations with multiple enzyme-like activities.
About this collection
Welcome to our online rolling collection of the hottest work published in Biomaterials Science. Here we feature recent Biomaterials Science articles highlighted as HOT by the handling editor or our referees.
Congratulations to all the authors whose articles are featured.