Themed collection Biomaterials Science Recent HOT Articles

The discovery of CRISPR/Cas9 genome-editing technology enables the precise manipulation of mammalian DNA sequences for treating genetic disorders.

Application of phase change materials (PCMs) in biomedical field.

Nanofibers constructed by an in situ self-assembly strategy hold tremendous promise for cancer theranostics with characteristic functions and biological effects in different parts of tumor tissue.

Nanomedicine recognition and clearance by the mononuclear phagocyte system (MPS) impedes optimal clinical impacts for this class of materials. We present an overview of factors involved in MPS interactions and approaches to overcome this barrier.

Protein crystal engineering both in vitro and within cells has led to advances in protein crystallization and generation of solid functional materials.

Over the decades, researchers have strived to synthesize and modify nature-inspired biomaterials, with the primary aim to address the challenges of designing functional biomaterials for regenerative medicine and tissue engineering.

This review provides an overview of engineering cellular membranes with deoxyribonucleic acids to manipulate cellular behaviors and functionalities for biomedical applications. The current challenges and future directions are summarized and proposed.

This comprehensive review brings a larger perspective on the most recent developments in new tissue-scaffolds based on marine origin polymers envisaging the treatment and repair of human articular cartilage tissues.

Various types of celastrol nanoformulations have been developed to treat a number of disorders, including cancer, inflammatory, auto-immune, obesity.

Based on the fluorescence off–on principle, a dye-labeled Au nanoflare tracer is presented for in vivo tracking the secretion of hepatocyte growth factor (HGF) by MSCs during idiopathic pulmonary fibrosis (IPF) therapy.

Interleukin (IL)-22 is a multifunctional cytokine with a very short half-life that activates STAT3 and can elicit an anti-inflammatory response. We show encapsulation of IL-22 in LPMSN enhances its biological activity and stability in in vitro and human colonic organoids.

We demonstrate the feasibility of subcutaneously implanted fluorescent diamond microparticles as a temperature probe for the non-contact measurement of internal body temperature using a homemade wide-field optically detected magnetic resonance imager.

Bioadhesive hydrogel patches based on chemically modified photocrosslinkable polymers with specific physicochemical properties for sealing and repair of ocular injuries.

A smart skin regeneration platform that can enhance their selective cellular uptake to fibroblasts via PAR-2 receptor mediated endocytosis is proposed.

GSH depleting prodrugs and ROS generators self-assemble to generate oxidative stress nanoamplifiers that can preferentially kill cancer cells and exert immunostimulating activity.

The proposed photoclick HC–HN bioink expands the palette of available polysaccharide-based bioinks and greatly extends the biofabrication window to broaden the application opportunities of 3D bioprinting.

An injectable adhesive hydrogel based on N-hydroxysuccinimide γ-poly(glutamic acid) and 4-armed poly(ethylene glycol) amine showed rapid gelation time, strong mechanical strength, satisfactory burst pressure and excellent hemostatic performance.

Flash nanotechnology-produced nanomedicines exhibit potent antioxidant and anti-inflammatory properties and could overcome mucosal barrier for oral delivery, resulting in great efficiency in the prevention and treatment of colitis-associated colorectal cancer.

A component-optimized chemo-dynamic nanoagent achieved an enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model.

Biodegradable peptide polymers display potent and broad-spectrum antibacterial activity in vitro, as well as strong therapeutic potential in vivo, as a promising alternative to antibiotics in aquaculture.

A multifunctional nanoplatform has been developed based on boron nanosheets loaded quaternized chitosan and NO donor N,N′-di-sec-butyl-N,N′-dinitroso-1,4-phenylenediamine for rapid, and effective treatment of pathogenic bacteria.

Plant-inspired gallol-containing surfactants have been successfully incorporated into typical Pluronic® micelles, allowing low critical micelle concentration, great colloidal stability, and exterior enzyme resistance.

Lymph node-inspired 3D hydrogels with precisely defined porosity were produced, which improve the state-of-the-art T cell proliferation, a procedure that is especially important for novel cellular immunotherapies.

The polymer dual drug conjugate synthesized by coupling docetaxel (DTX) and docosahexaenoic acid (DHA) with bifunctionalized dextran is selectively accumulated in tumor and nearly eradicates all MCF-7 tumors bearing in nude mice.

Fatty acid-tethered polymers were synthesized via RAFT method to explore their potential role in preventing insulin aggregation process. The results endowed fatty acid-tethered polymers with properties to act as novel anti-amyloidogenic agents.

Polycaprolactone/silica hybrids offer a dual therapeutic effect: the promotion of bone regeneration thanks to silicate ions and strong antibacterial properties against the risk of osteomyelitis.

By developing DPA-TPE-DCM with intense near-infrared fluorescence emission in the aggregation state, AIE materials were used for the first time in the early diagnosis of orthotopic TSCC and SLN mapping in an orthotopic TSCC-bearing mouse model.

Amphiphilic cationic anticancer lipopeptide P10 self-assembles into spherical aggregates, which are used as drug carriers to play a synergistic anticancer role, and its anticancer mechanism is presented.

A bionic biphasic composite scaffold with on-demand osteochondrogenic factors facilitated the regeneration of osteochondral defects.

The local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration via synergistic immunomodulation of osteogenesis and osteoclastogenesis by macrophages.

In this work, capillary tubes with different diameters were chosen to mimic a confined environment and the effect of space on the self-assembly behavior of short peptides with different oil-water partition coefficients (log P) was investigated.

We have designed a dual-function microneedle patch that integrates treatment and diagnosis.

Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance.

A kind of blood-repellent mist spray (MS) was proposed to prevent blood adhesion during surgery and played an important role in antibacterial and wound-healing, which could be widely used in the surface modification of various medical gloves.

Stroke activated Endothelial Cells recruit leucocytes for further necrosis. Esbp-PEG-lipid modified cells can bind to these ECs for a rather protective effect and reduced leucocyte binding.

3D tumor spheroid/NK co-culture platform facilitates the discovery of a small drug, C19, for synergistic NK-mediated cytolysis against pancreatic cancer patient-derived cancer spheroid.

Antimicrobial peptide hydrogels combined with phototherapy in the treatment of infected wounds.

Here we align airway epithelial cells on hydrogel grooves and induce apical-basal polarization and cilia formation. Neither initial alignment, nor maintained alignment on the grooves induced polarized cilia alignment in the epithelial sheet.

Evaluating the host immune response to biomaterials is an essential step in the development of medical devices and tissue engineering strategies.

mSA-CBM3-AzF is a chimeric protein targeting cellulose nanocrystals (CNCs) with high affinity. It presents two additional domains providing a wide choice of chemical and biological molecules to functionalize CNCs.

The role of molecular mobility on polyrotaxane surfaces was investigated in epithelial cell–cell adhesion. The polyrotaxane surfaces with higher mobility induced cytoplasmic YAP localization, leading to stronger cell–cell adhesion.

The coating of tobacco mosaic virus (TMV) nanoparticles Gd-Cy5-TMV with polydopamine (PDA) increased protein corona formation and shortened plasma circulation, but minimized recognition by anti-TMV antibodies, and extended organ distribution/clearance.

A green multifunctional wound dressing with low-cost that can accelerate wound healing in comparison to gauze.

The dual-sensitive dual-prodrug nanoparticles (DDNPs) with light-controlled drug-release on demand and endo/lysosomal escape for synergistic photoactivated chemotherapy.

Mechanobiology of H9C2 cells and neonatal cardiomyocytes mapped using stiffness gradient hydrogels with a range of extracellular matrix coatings, revealing stiffness-driven trends in cell morphology, YAP and MRTF-A expression.

Droplet microarrays are fabricated for the high-throughput screening of drug-eluting coatings via ultrasonic spray deposition technique.

MIL-100(Fe) nanoparticles integrated microneedles were employed to codeliver the hydrophobic photosensitizer zinc phthalocyanine (ZnPc) and the chemotherapeutical drug doxorubicin hydrochlorate (Dox) (Z/D@MOF) for O₂-evolving chemophototherapy.

c-Met-targeted near-infrared fluorescent probe has excellent targeting ability to pancreatic ductal adenocarcinoma (PDAC), and can be used for real-time detection of lymph node metastasis and perineural invasion lesions in PDAC xenograft models.

A pre-shear bioprinting strategy of oriented porous cell-laden hydrogel microfiber to construct anisotropic tissues is first proposed. Different cells encapsulated in the oriented microfibers exhibit oriented growth behaviors similar to that in vivo.

Advanced drug vehicle exploitation and the sophisticated synergy mechanism revelation are two great difficulties in combination therapy.

We developed a mono-component and sulfonate-based polypeptide coating with reversible on-demand bactericidal and antifouling properties.

This article reports a high-stability NIR-II fluorescence polymer synthesized by atom transfer radical polymerization for application in high-resolution NIR-II imaging.

Single tumor starvation therapy can activate other signaling pathways in tumor cells and easily induce tumor cell metastasis.

Sonodynamic therapy (SDT) is a fast-growing therapy activated by using ultrasound to initiate a catalytic reaction of sensitizing agents and kill tumor cells through producing reactive oxygen species (ROS).

An illustration of black phosphorus (BP) assisted polyionic mPEG-PDMATC micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumors.

A reliable approach is developed to formulate a targeted lipid-coated nanomedicine based on UCNP and co-loaded with CO-prodrug and vitamin E, which can convert NIR light to UV photon to release CO for synergistical cancer therapy with vitamin E.

A pH-triggered fluorescence-switchable extracellular vesicle is developed by loading zwitterionic fluorescent carbon dots into macrophage cell-secreted vesicles, which enables to improve drug delivery and monitor drug release in real time.

Polyampholyte hydrogels are attractive materials for tissue engineering scaffolds as they offer a wide variety of features including nonfouling, selective protein delivery, and tunable physical characteristics.