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Issue 1, 2016
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Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC

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Abstract

We synthesized a miR-122 antimiR library in which drug-like fragments were site-specifically introduced to short 2′-O-methyl-RNAs. At some sites selected fragments elevated cellular antimiR activity to that of an unmodified 23mer antimiR, whereas at others the same fragments abolished activity. The potency of the antimiRs correlated with uptake into miRISC.

Graphical abstract: Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC

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Supplementary files

Article information


Submitted
06 Sep 2015
Accepted
17 Oct 2015
First published
27 Oct 2015

This article is Open Access

Chem. Commun., 2016,52, 156-159
Article type
Communication
Author version available

Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC

A. Brunschweiger, L. F. R. Gebert, M. Lucic, U. Pradère, H. Jahns, C. Berk, J. Hunziker and J. Hall, Chem. Commun., 2016, 52, 156
DOI: 10.1039/C5CC07478A

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