Issue 64, 2014
From the journal:

Chemical Communications

Total synthesis of the cyanobacterial metabolite nostodione A: discovery of its antiparasitic activity against Toxoplasma gondii†

J. McNulty,*a   K. Keskar,a   C. Bordón,b   R. Yolkenb  and  L. Jones-Brandob  

* Corresponding authors

a Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada L8S 4M1
E-mail: jmcnult@mcmaster.ca
Tel: +1-905-525-9140 ext. 27393

b Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland, USA

Abstract

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time.

Graphical abstract: Total synthesis of the cyanobacterial metabolite nostodione A: discovery of its antiparasitic activity against Toxoplasma gondii

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Article information

DOI
https://doi.org/10.1039/C4CC03904A
Article type
Communication
Submitted
22 May 2014
Accepted
12 Jun 2014
First published
19 Jun 2014

Chem. Commun., 2014,50, 8904-8907

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Total synthesis of the cyanobacterial metabolite nostodione A: discovery of its antiparasitic activity against Toxoplasma gondii

J. McNulty, K. Keskar, C. Bordón, R. Yolken and L. Jones-Brando, Chem. Commun., 2014, 50, 8904 DOI: 10.1039/C4CC03904A

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