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Issue 64, 2014
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Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium

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Abstract

The first regioselective ortho-lithiation at the 4-position of simple pyridine derivatives containing a 3-oxetane unit has been achieved using n-butyllithium as base. Electrophilic quenching of the resulting lithio species provides a rapid access to a broad range of new functionalized pyridine oxetane building blocks.

Graphical abstract: Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium

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Publication details

The article was received on 16 May 2014, accepted on 19 Jun 2014 and first published on 20 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC03766A
Chem. Commun., 2014,50, 8908-8911
  • Open access: Creative Commons BY license
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    Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium

    G. Rouquet, D. C. Blakemore and S. V. Ley, Chem. Commun., 2014, 50, 8908
    DOI: 10.1039/C4CC03766A

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