Issue 71, 2022

Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

Abstract

The coordination chemistry of Ra2+ is poorly defined, hampering efforts to design effective chelators for 223Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra2+ with the biomedically-relevant chelators DOTA and macropa. Our work reveals the highest affinity chelator to date for Ra2+ and advances our understanding of key factors underlying complex stability and selectivity for this underexplored ion.

Graphical abstract: Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

Supplementary files

Article information

Article type
Communication
Submitted
06 Jun 2022
Accepted
12 Aug 2022
First published
19 Aug 2022

Chem. Commun., 2022,58, 9938-9941

Author version available

Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

A. S. Ivanov, M. E. Simms, V. S. Bryantsev, P. D. Benny, J. R. Griswold, L. H. Delmau and N. A. Thiele, Chem. Commun., 2022, 58, 9938 DOI: 10.1039/D2CC03156F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements