Plasma flow chemistry for direct N-acylation of amines by esters

Elias Abedelnour; Stephanie Ognier; Mengxue Zhang; Laurent Schio; Olivier Venier; Janine Cossy; Michael Tatoulian

doi:10.1039/D2CC01940J

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Plasma flow chemistry for direct N-acylation of amines by esters†

Elias Abedelnour,

^ab Stephanie Ognier,^a Mengxue Zhang,^a Laurent Schio,^b Olivier Venier,^b Janine Cossy

*^c and Michael Tatoulian*^a

Author affiliations

* Corresponding authors

^a Chimie Paristech, PSL University, CNRS, Institut de Recherche de Chimie Paris, UMR8247, 11 rue Pierre et Marie Curie, 75005 – Paris, France
E-mail: michael.tatoulian@chimieparistech.psl.eu

^b Sanofi, Integrated Drug Discovery – IDD France, 1 Avenue Pierre Brossolette – Chilly Mazarin, France

^c Molecular, Macromolecular Chemistry and Materials (C3M), ESPCI Paris, PSL University, CNRS, 75005 – Paris, France
E-mail: janine.cossy@espci.fr

Abstract

The direct N-acylation of amines by esters in a microreactor is described using argon plasma, thereby producing amides in good to excellent yields.

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Article information

DOI: https://doi.org/10.1039/D2CC01940J
Article type: Communication
Submitted: 11 Apr 2022
Accepted: 20 May 2022
First published: 09 Jun 2022

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Chem. Commun., 2022,58, 7281-7284

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Plasma flow chemistry for direct N-acylation of amines by esters

E. Abedelnour, S. Ognier, M. Zhang, L. Schio, O. Venier, J. Cossy and M. Tatoulian, Chem. Commun., 2022, 58, 7281 DOI: 10.1039/D2CC01940J

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Chemical Communications

Plasma flow chemistry for direct N-acylation of amines by esters†

Abstract

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Plasma flow chemistry for direct N-acylation of amines by esters

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