Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions†
Roberto
del Río-Rodríguez, 
‡a
Matthew T.
Westwood,
‡b
Marina
Sicignano,
a
Martin
Juhl,
b
Jose A.
Fernández-Salas,
ac
José
Alemán
*acd
and
Andrew D.
Smith
*b
‡a
Matthew T.
Westwood,
‡b
Marina
Sicignano,
a
Martin
Juhl,
b
Jose A.
Fernández-Salas,
ac
José
Alemán
*acd
and
Andrew D.
Smith
*b
Abstract
The photocatalytic generation of α-amino radicals is combined with chiral isothiourea derived α,β-unsaturated acyl ammonium intermediates. The reaction proceeds VIA a [3+2] radical-polar crossover mechanism to generate γ-lactams in good yields and enantioselectivities. The enantioselective radical conjugate addition was carried out under batch and flow conditions.
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