Issue 52, 2022
From the journal:

Chemical Communications

Rapid and sensitive multiplex detection of COVID-19 antigens and antibody using electrochemical immunosensor-/aptasensor-enabled biochips†

Fuze Jiang,‡ab   Zhen Xiao,‡cd   Ting Wang,e   Jiajia Wang,cdf   Lihua Bie,g   Lanja Saleh,h   Kathrin Frey,h   Lianjun Zhang*cd  and  Jing Wang ORCID logo *ab  

* Corresponding authors

a Institute of Environmental Engineering, ETH Zürich, Zürich, Switzerland
E-mail: jing.wang@ifu.baug.ethz.ch

b Advanced Analytical Technologies, Empa, Dübendorf, Switzerland

c CAMS Key Laboratory of Synthetic Biology Regulatory Element, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
E-mail: zlj@ism.cams.cn

d Suzhou Institute of Systems Medicine, Suzhou 215123, China

e School of Automation, Hangzhou Dianzi University, Hangzhou 310018, China

f School of Engineering, China Pharmaceutical University, Nanjing, China

g College of Informatics, Huazhong Agricultural University, Wuhan 430070, Hubei, China

h Institute of Clinical Chemistry, University Hospital Zurich, University of Zurich, Zurich 8091, Switzerland

Abstract

We report protein- and aptamer-based electrochemical biochips for low-cost, one-step, sensitive and accurate multiplex detection of SARS-CoV-2 spike (S) and nucleocapsid (N) proteins, and IgG antibody in unprocessed clinical samples, allowing citizens to achieve rapid diagnosis at home or in community settings.

Graphical abstract: Rapid and sensitive multiplex detection of COVID-19 antigens and antibody using electrochemical immunosensor-/aptasensor-enabled biochips

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Article information

DOI
https://doi.org/10.1039/D2CC01598F
Article type
Communication
Submitted
21 Mar 2022
Accepted
26 May 2022
First published
26 May 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 7285-7288

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Rapid and sensitive multiplex detection of COVID-19 antigens and antibody using electrochemical immunosensor-/aptasensor-enabled biochips

F. Jiang, Z. Xiao, T. Wang, J. Wang, L. Bie, L. Saleh, K. Frey, L. Zhang and J. Wang, Chem. Commun., 2022, 58, 7285 DOI: 10.1039/D2CC01598F

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