Issue 18, 2021
From the journal:

Organic & Biomolecular Chemistry

Lewis acid mediated cyclization: synthesis of 2 spirocyclohexylindolines†

Xiang-Kai Kong,a   Zhi-Min Xiong,a   Xiang Zhi,a   Xue-Ling Meng,a   Jing-Feng Zhao,a   Wen Chen*a  and  Hongbin Zhang ORCID logo *a  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research and Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, P. R. China
E-mail: wenchen@ynu.edu.cn, zhanghb@ynu.edu.cn

Abstract

Herein, we report the synthesis of 2-spirocyclohexylindolines based on a Lewis acid mediated cyclization. This diastereoselective procedure provides the target structures in a straightforward way via dual activation.

Graphical abstract: Lewis acid mediated cyclization: synthesis of 2 spirocyclohexylindolines

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Article information

DOI
https://doi.org/10.1039/D1OB00293G
Article type
Communication
Submitted
17 Feb 2021
Accepted
29 Mar 2021
First published
30 Mar 2021

Org. Biomol. Chem., 2021,19, 4043-4047

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Lewis acid mediated cyclization: synthesis of 2 spirocyclohexylindolines

X. Kong, Z. Xiong, X. Zhi, X. Meng, J. Zhao, W. Chen and H. Zhang, Org. Biomol. Chem., 2021, 19, 4043 DOI: 10.1039/D1OB00293G

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