Ruthenium-catalyzed regio- and site-selective ortho C–H borylation of phenol derivatives

Abstract

Efficient synthesis of o-borylphenols is achieved through the Ru-catalyzed regio- and site-selective sp² C–H borylation of aryl diphenylphosphinites followed by removal of the phosphorus directing group. A successful application to aryl phosphites enables practical one-pot borylation of phenols, demonstrating high synthetic utility of this protocol.