Issue 73, 2020
From the journal:

Chemical Communications

Fatty acid-like Pt(iv) prodrugs overcome cisplatin resistance in ovarian cancer by harnessing CD36†

Amarasooriya M. D. S. Jayawardhana,a   Morgan Stilgenbauer,a   Payel Datta,a   Zihan Qiu,a   Sarine Mckenzie,a   Han Wang,a   David Bowers,a   Manabu Kurokawab  and  Yao-Rong Zheng ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, USA
E-mail: yzheng7@kent.edu

b Department of Biological Sciences, Kent State University, Kent, OH 44242, USA

Abstract

Resistance to the platinum-based chemotherapy drug, cisplatin, is a significant setback in ovarian cancer. We engineered fatty acid-like Pt(IV) prodrugs that harness the fatty acid transporter CD36 to facilitate their entry to ovarian cancer cells. We show that these novel constructs effectively kill cisplatin-resistant ovarian cancer cells.

Graphical abstract: Fatty acid-like Pt(iv) prodrugs overcome cisplatin resistance in ovarian cancer by harnessing CD36

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Article information

DOI
https://doi.org/10.1039/D0CC02174A
Article type
Communication
Submitted
24 Mar 2020
Accepted
05 Aug 2020
First published
05 Aug 2020

Chem. Commun., 2020,56, 10706-10709

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Fatty acid-like Pt(IV) prodrugs overcome cisplatin resistance in ovarian cancer by harnessing CD36

A. M. D. S. Jayawardhana, M. Stilgenbauer, P. Datta, Z. Qiu, S. Mckenzie, H. Wang, D. Bowers, M. Kurokawa and Y. Zheng, Chem. Commun., 2020, 56, 10706 DOI: 10.1039/D0CC02174A

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