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KI- catalyzed reaction of aryl hydrazines with α-oxocarboxylic acids in the presence of CO2: access to 1,3,4-oxadiazol-2(3H)-ones

Abstract

A novel KI-catalyzed synthesis of 1,3,4-oxadiazol-2(3H)-ones from aryl hydrazines and α-oxocarboxylic acids and CO2 was reported. This process could effectively utilize CO2 from the decarboxylation of α-oxocarboxylic acids and afford the target products in good to excellent yields under mild conditions. It was demonstrated that the active IO– ions from the reaction of KI and TBHP oxidant played an important role in this transformation, and the reaction did not involve a free radical process.

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Publication details

The article was received on 12 Dec 2018, accepted on 09 Jan 2019 and first published on 10 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01345D
Citation: Org. Chem. Front., 2019, Accepted Manuscript
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    KI- catalyzed reaction of aryl hydrazines with α-oxocarboxylic acids in the presence of CO2: access to 1,3,4-oxadiazol-2(3H)-ones

    N. Yang, H. Zhang and G. Yuan, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C8QO01345D

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