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Issue 32, 2015
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POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

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Abstract

The increasing use of nanoparticles in the pharmaceutical industry is generating concomitant interest in developing nanomaterials that can rapidly penetrate into, and permeate through, biological membranes to facilitate drug delivery and improve the bioavailability of active pharmaceutical ingredients. Here, we demonstrate that the permeation of thiolated silica nanoparticles through porcine gastric mucosa can be significantly enhanced by their functionalization with either 5 kDa poly(2-ethyl-2-oxazoline) or poly(ethylene glycol). Nanoparticle diffusion was assessed using two independent techniques; Nanoparticle Tracking Analysis, and fluorescence microscopy. Our results show that poly(2-ethyl-2-oxazoline) and poly(ethylene glycol) have comparable abilities to enhance diffusion of silica nanoparticles in mucin dispersions and through the gastric mucosa. These findings provide a new strategy in the design of nanomedicines, by surface modification or nanoparticle core construction, for enhanced transmucosal drug delivery.

Graphical abstract: POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

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Publication details

The article was received on 14 May 2015, accepted on 14 Jul 2015 and first published on 17 Jul 2015


Article type: Paper
DOI: 10.1039/C5NR03178H
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Citation: Nanoscale, 2015,7, 13671-13679
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    POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

    E. D. H. Mansfield, K. Sillence, P. Hole, A. C. Williams and V. V. Khutoryanskiy, Nanoscale, 2015, 7, 13671
    DOI: 10.1039/C5NR03178H

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