Issue 45, 2015
From the journal:

Chemical Communications

A simple fluorescent off–on probe for the discrimination of cysteine from glutathione†

Xinghui Gao,a   Xiaohua Li,*a   Lihong Li,a   Jin Zhoua  and  Huimin Ma*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: mahm@iccas.ac.cn, lixh@iccas.ac.cn

Abstract

A simple and stable fluorescent off–on probe for discrimination of cysteine (Cys) from glutathione (GSH) has been developed by combining resorufin with 7-nitrobenzofurazan. The probe, displaying distinct emission patterns for Cys and GSH at just one excitation wavelength, can be used for simultaneous determination of Cys and GSH in human plasma.

Graphical abstract: A simple fluorescent off–on probe for the discrimination of cysteine from glutathione

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Article information

DOI
https://doi.org/10.1039/C5CC02788H
Article type
Communication
Submitted
03 Apr 2015
Accepted
01 May 2015
First published
01 May 2015

Chem. Commun., 2015,51, 9388-9390

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A simple fluorescent off–on probe for the discrimination of cysteine from glutathione

X. Gao, X. Li, L. Li, J. Zhou and H. Ma, Chem. Commun., 2015, 51, 9388 DOI: 10.1039/C5CC02788H

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