Global gene expression distribution in non-cancerous complex diseases

Yun Wu; Nana Jin; Haiyang Zhu; Chunmiao Li; Nannan Liu; Yan Huang; Zhengqiang Miao; Xiaoman Bi; Deng Wu; Xi Chen; Yun Xiao; Dapeng Hao; Chuanxing Li; Binsheng Gong; Shaojun Zhang; Liwei Zhuang; Kongning Li; Dong Wang

doi:10.1039/C3MB70524B

Global gene expression distribution in non-cancerous complex diseases

Yun Wu,†^a Nana Jin,†^a Haiyang Zhu,†^b Chunmiao Li,^a Nannan Liu,^a Yan Huang,^a Zhengqiang Miao,^a Xiaoman Bi,^a Deng Wu,^a Xi Chen,^a Yun Xiao,^a Dapeng Hao,^a Chuanxing Li,^a Binsheng Gong,^a Shaojun Zhang,^a Liwei Zhuang,*^a Kongning Li*^a and Dong Wang*^a

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^a College of Bioinformatics Science and Technology, the Fourth Affiliated Hospital, Harbin Medical University, 157 Baojian Road, Harbin, China
E-mail: wangdong@ems.hrbmu.edu.cn, kongningli@hotmail.com, zhuangliweiyd@126.com
Tel: +86 045186699584

^b The infection department, fifth affiliated hospital of Zhengzhou University, Zhengzhou, China

Abstract

For gene expression in non-cancerous complex diseases, we systemically evaluated the sensitivities of biological discoveries to violation of the common normalization assumption. Our results indicated that gene expression may be widely up-regulated in digestive system and musculoskeletal diseases. However, global signal intensities showed little difference in other four disease types.

Molecular BioSystems

Global gene expression distribution in non-cancerous complex diseases

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Global gene expression distribution in non-cancerous complex diseases

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