The critical residues of helix 5 for in vitro pentamer formation and stability of the papillomavirus capsid protein, L1†
Abstract
The mono-site mutations of the absolutely conserved residues, 464LGR466, in the α-helix 5 (h5) of HPV16 L1 completely disrupted the pentamer formation. The implication of this finding is the potential usage of a h5-like peptide as the reagent to interfere with the pentamer formation and stability as an anti-HPV reagent.