Issue 10, 2012
From the journal:

Organic & Biomolecular Chemistry

A selective fluorescent turn-on NIR probe for cysteine†

Xin-Dong Jiang,*a   Jian Zhang,a   Xiangmin Shaoa  and  Weili Zhao*ab  

* Corresponding authors

a The Key Laboratory for Special Functional Materials, Ministry of Education, Henan University, Henan, China
E-mail: xdjiang@henu.edu.cn, zhaow@henu.edu.cn
Tel: +86 0378 3881358

b School of Pharmacy, Fudan University, Shanghai, China
Tel: +86 021 51980111

Abstract

A selective and sensitive turn-on fluorescent NIR probe for cysteine has been developed. Cleavage of 2,4-dinitrobenzenesulfonyl (DNBS) with thiols switches the weakly fluorescent aza-BODIPY dye (λem = 734 nm, Φf = 0.03) to a strongly fluorescent species in the NIR region (λem = 755 nm, Φf = 0.14).

Graphical abstract: A selective fluorescent turn-on NIR probe for cysteine

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Article information

DOI
https://doi.org/10.1039/C2OB07046D
Article type
Communication
Submitted
07 Dec 2011
Accepted
16 Jan 2012
First published
17 Jan 2012

Org. Biomol. Chem., 2012,10, 1966-1968

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A selective fluorescent turn-on NIR probe for cysteine

X. Jiang, J. Zhang, X. Shao and W. Zhao, Org. Biomol. Chem., 2012, 10, 1966 DOI: 10.1039/C2OB07046D

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