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Issue 2, 2012
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Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

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Abstract

Here, we report that thiol-mediated decomposition of 2,3-epoxy-1,4-naphthoquinones to generate peroxide, a reactive oxygen species (ROS), could be modulated by changing the substitution pattern on the aryl ring and the epoxide. Epoxides which generated higher amounts of peroxide upon reaction with thiols were better inhibitors of human leukaemia (THP1) cell proliferation.

Graphical abstract: Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

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Article information


Submitted
14 Sep 2011
Accepted
17 Oct 2011
First published
26 Oct 2011

Med. Chem. Commun., 2012,3, 219-224
Article type
Concise Article

Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

A. T. Dharmaraja, T. K. Dash, V. B. Konkimalla and H. Chakrapani, Med. Chem. Commun., 2012, 3, 219
DOI: 10.1039/C1MD00234A

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