Issue 13, 2011
From the journal:

Organic & Biomolecular Chemistry

Highly enantioselective aldol reaction of acetone with β,γ-unsaturated α-keto esters promoted by simple chiral primary–tertiary diaminecatalysts

Lin Peng,ab   Liang-Liang Wang,ab   Jian-Fei Bai,ab   Li-Na Jia,ab   Yun-Long Guo,ab   Xi-Ya Luo,ab   Fei-Ying Wang,a   Xiao-Ying Xu*a  and  Li-Xin Wang*a  

* Corresponding authors

a Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China
E-mail: wlxioc@cioc.ac.cn, xuxy@cioc.ac.cn
Fax: +86-028-8525-5208

b Graduate School of Chinese Academy of Sciences, Beijing 10039, People's Republic of China

Abstract

A series of primary–tertiary diamine catalysts were successfully applied to promote the enantioselective aldol reaction of acetone with β,γ-unsaturated α-keto esters in excellent yields (up to 99%) and enantioselectivities (up to 96% ee).

Graphical abstract: Highly enantioselective aldol reaction of acetone with β,γ-unsaturated α-keto esters promoted by simple chiral primary–tertiary diamine catalysts

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Article information

DOI
https://doi.org/10.1039/C1OB05607G
Article type
Communication
Submitted
15 Apr 2011
Accepted
11 May 2011
First published
11 May 2011

Org. Biomol. Chem., 2011,9, 4774-4777

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Highly enantioselective aldol reaction of acetone with β,γ-unsaturated α-keto esters promoted by simple chiral primary–tertiary diamine catalysts

L. Peng, L. Wang, J. Bai, L. Jia, Y. Guo, X. Luo, F. Wang, X. Xu and L. Wang, Org. Biomol. Chem., 2011, 9, 4774 DOI: 10.1039/C1OB05607G

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