Issue 13, 2011
From the journal:

Organic & Biomolecular Chemistry

Conia-ene annulation of the α-cyano β-TMS-capped alkynyl cycloalkanone system and its synthetic application†

Chih-Lung Chin,a   Cheng-Feng Liao,a   Hsing-Jang Liu,a   Ying-Chieh Wong,b   Ming-Tsang Hsieh,b   Prashanth K. Amancha,b   Chun-Ping Changb  and  Kak-Shan Shia*b  

* Corresponding authors

a Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, ROC

b Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, Taiwan, ROC
E-mail: ksshia@nhri.org.tw
Fax: +886-37-586-456
Tel: +886-37-246-166

Abstract

Under catalysis with ZnI2, an effective annulation process of ω-silylacetylenic α-cyano ketones, leading to the formation of various bicyclic frameworks characterized with a TMS-containing methylenecyclopentane ring, has been developed.

Graphical abstract: Conia-ene annulation of the α-cyano β-TMS-capped alkynyl cycloalkanone system and its synthetic application

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Article information

DOI
https://doi.org/10.1039/C1OB05591G
Article type
Communication
Submitted
13 Apr 2011
Accepted
11 May 2011
First published
11 May 2011

Org. Biomol. Chem., 2011,9, 4778-4781

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Conia-ene annulation of the α-cyano β-TMS-capped alkynyl cycloalkanone system and its synthetic application

C. Chin, C. Liao, H. Liu, Y. Wong, M. Hsieh, P. K. Amancha, C. Chang and K. Shia, Org. Biomol. Chem., 2011, 9, 4778 DOI: 10.1039/C1OB05591G

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