Issue 14, 2002
From the journal:

Journal of the Chemical Society, Dalton Transactions

Crystallographic and NMR evidence of the unusual N6,N7-didentate chelation of 3-methyladenine coordinated to the cytotoxic α-dichlorobis(2-phenylazopyridine)ruthenium(ii) complex†

Anna C. G. Hotze,a   Marjolein E. T. Broekhuisen,a   Aldrik H. Velders,a   Huub Kooijman,b   Anthony L. Spek,b   Jaap G. Haasnoota  and  Jan Reedijk*a  

* Corresponding authors

a Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 RA leiden, The Netherlands
E-mail: reedijk@chem.leidenuniv.nl

b Bijvoet Center of Biomolecular research, Crystal and Structural Chemistry Utrecht University, Padualaan 8, Utrecht, 3584 CH, The Netherlands
E-mail: h.kooijman@chem.uu.nl

Abstract

Adenine bases have recently been found to coordinate to the cytotoxic alpha isomer of dichlorobis(2-phenylazopyridine)ruthenium(II) complexes in the rare imine form, stabilised by N6,N7-didentate coordination, which is now proven by X-ray structure determination of the compound α-[Ru(azpy)2(3-MeAde−H)]PF6 (azpy = 2-phenyl-azopyridine, 3-MeAde−H = deprotonated 3-methyladenine).

Graphical abstract: Crystallographic and NMR evidence of the unusual N6,N7-didentate chelation of 3-methyladenine coordinated to the cytotoxic α-dichlorobis(2-phenylazopyridine)ruthenium(ii) complex

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Article information

DOI
https://doi.org/10.1039/B204665M
Article type
Communication
Submitted
14 May 2002
Accepted
13 Jun 2002
First published
26 Jun 2002

J. Chem. Soc., Dalton Trans., 2002, 2809-2810

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Crystallographic and NMR evidence of the unusual N6,N7-didentate chelation of 3-methyladenine coordinated to the cytotoxic α-dichlorobis(2-phenylazopyridine)ruthenium(II) complex

A. C. G. Hotze, M. E. T. Broekhuisen, A. H. Velders, H. Kooijman, A. L. Spek, J. G. Haasnoot and J. Reedijk, J. Chem. Soc., Dalton Trans., 2002, 2809 DOI: 10.1039/B204665M

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