Enone 8, a key intermediate in the preparation of 4,5-didehydro prostaglandins via a two component coupling process, is prepared efficiently from readily available enone 6; the synthesis of enprostil, an antiulcer agent developed by Syntex, using enone 8 is also described.
N. Ono, Y. Kawanaka, Y. Yoshida and F. Sato, J. Chem. Soc., Chem. Commun., 1994, 1251 DOI: 10.1039/C39940001251
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