Enolate Claisen rearrangement of the lactone 7 leads to the tetrahydrofuran (THF) ester 9 as a single diastereoisomer, reduction of which gives the general bis-THF lignan precursor 2.
H. M. Bradley and D. W. Knight, J. Chem. Soc., Chem. Commun., 1991, 1641 DOI: 10.1039/C39910001641
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