Issue 22, 1991

Efficient intramolecular general acid catalysis of vinyl ether hydrolysis by the neighbouring carboxylic acid group

Abstract

Intramolecular catalysis by the CO2H group of the hydrolysis of E-1-methoxy-2-(2-carboxyphenyl)ethylene 5, shows an effective molarity of almost 300 M, the highest measured for intramolecular proton transfer to carbon.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1991, 1643-1644

Efficient intramolecular general acid catalysis of vinyl ether hydrolysis by the neighbouring carboxylic acid group

A. J. Kirby and N. H. Williams, J. Chem. Soc., Chem. Commun., 1991, 1643 DOI: 10.1039/C39910001643

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