Homochiral α-fluoroketones from racemic α-fluorocarboxylic esters and enantiomerically pure sulphoxides

Abstract

The α-fluoroalkyl ketones (3–7) carrying an alkyl, alkenyl, hydroxymethyl, or formyl residue were obtained in enantiomerically pure form by removing, by various methods, the auxiliary sulphinyl group from the α-fluoro α′-sulphinyl ketones (1) and (2) derived from chiral sulphoxides and commercially available α-fluorocarboxylic acids.